Understanding the Role of Neighborhood Deprivation in Racial Disparities in Triple-negative Breast Cancer.

Details

• Alternative Title:
  Cancer, 2025, v. 131, no. 21: Understanding the Role of Neighborhood Deprivation in Racial Disparities in Triple-negative Breast Cancer.
• Journal Article:
  Cancer
• Personal Author:
  Barber, Lauren E. ; Maliniak, Maret L. ; Miller-Kleinhenz, Jasmine M. ; Moubadder, Leah ; Smith-Graziani, Demetria ; Switchenko, Jeffrey M. ; Ward, Kevin C. ; McCullough, Lauren E.
• Description:
  US Black women are twice as likely to be diagnosed with triple-negative breast cancer (TNBC), an aggressive subtype, as White women. Adverse neighborhood characteristics may contribute to the disparity. This study examined neighborhood deprivation in relation to TNBC, according to race and rurality.
  
  The authors identified 40,095 non-Hispanic Black and White women diagnosed with invasive breast cancer in 2010-2017 in the Georgia Cancer Registry. The Neighborhood Deprivation Index (NDI), a composite measure, was calculated using 2011-2015 block group-level American Community Survey data. County-level rurality was measured via Georgia Department of Public Health data. We estimated multivariable odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between NDI, in quintiles, and each breast cancer subtype (TNBC, HER2-enriched, luminal B vs. luminal A breast cancer), overall, and according to race and rurality.
  
  Compared to least deprived neighborhoods, living in the most deprived neighborhoods was associated with a 33% (OR, 1.33; 95% CI, 1.19-1.48) increased odds of TNBC versus luminal A breast cancer. Race and rurality did not modify the association. However, estimates were less pronounced among non-Hispanic Black women (OR, 1.18; 95% CI, 1.00-1.39 vs. OR, 1.40; 95% CI, 1.18-1.65 among non-Hispanic White women) and women living in urban counties (OR, 1.33; 95% CI, 1.18-1.50 vs. OR, 1.52; 95% CI, 1.15-2.03 in rural counties).
  
  In this study, neighborhood deprivation was associated with increased odds of TNBC, regardless of race or rurality. Given Black women are more likely to live in deprived neighborhoods, neighborhood deprivation may contribute to racial disparities in TNBC occurrence.
• Content Notes:
  Author manuscript
• Subjects:
  • Adult
  • Aged
  • Female
  • Humans
  • Middle Aged
  • Black or African American
  • Health Status Disparities
  • Neighborhood Characteristics
  • Registries
  • Residence Characteristics
  More +
• Keywords:
  • Neighborhood deprivation
  • Breast cancer subtype
  • Triple negative breast cancer
  • Racial disparities
  • Rurality
• Source:
  Cancer, 2025, v. 131, no. 21
• DOI:
  https://doi.org/10.1002/cncr.70138
• ISSN:
  0008-543X ; 1097-0142
• Pubmed ID:
  41128838
• Pubmed Central ID:
  PMC12747153
• Document Type:
  Text
• Funding:
  R00 CA267674/CA/NCI NIH HHSUnited States/ ; R00CA267674/CA/NCI NIH HHSUnited States/ ; R01 CA259192/CA/NCI NIH HHSUnited States/ ; HHSN261201800003I/CA/NCI NIH HHSUnited States/ ; R01CA259192/CA/NCI NIH HHSUnited States/ ; 6NU58DP006352-05-01/CC/CDC HHSUnited States/ ; HHSN261201000025C/CA/NCI NIH HHSUnited States/ ; HHSN26100001/CA/NCI NIH HHSUnited States/ ; HHSN261201800003C/CA/NCI NIH HHSUnited States/ ; R01CA259192-S1/CA/NCI NIH HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Georgia
• Pages in Document:
  e70138 (17 pdf pages)
• Volume:
  131
• Issue:
  21
• Download URL:
  https://stacks.cdc.gov/view/cdc/260992/cdc_260992_DS1.pdf
• File Type:
  [PDF - 135.09 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:99937f7ab05076be8b9f62bc1a3aedae45115de194f0913c9bba11d7b091fd4acd2a0161fa5ae8a5dd1d953a0d148b3c5c663097ca69b08942652bba5360c6a3