Perceived and Objective Physical Function in 2 United States Population-Based Cohorts of Adults With Systemic Lupus Erythematosus.

Details

• Alternative Title:
  The Journal of Rheumatology, 2026, v. 53, no. 6: Perceived and Objective Physical Function in 2 United States Population-Based Cohorts of Adults With Systemic Lupus Erythematosus.
• Journal Article:
  The Journal of Rheumatology
• Personal Author:
  Plantinga, Laura C. ; Fitzpatrick, Jessica ; Dey, Mrinalini ; Dall'Era, Maria ; Dunlop-Thomas, Charmayne ; Hoge, Courtney ; Lim, S. Sam ; Katz, Patricia P. ; Yazdany, Jinoos
• Description:
  We leveraged data from 2 population-based systemic lupus erythematosus (SLE) cohorts (Approaches to Positive, Patient-Centered Experiences of Aging With Lupus APPEAL and the California Lupus Epidemiology Study CLUES) to provide estimates of, and identify factors associated with, perceived and objective physical function (PF) and their discordance.
  
  Perceived PF (Patient-Reported Outcomes Measurement Information System PROMIS 12a/10a APPEAL/CLUES;
  
  -scores mean 50, SD 10) and objective PF (Short Physical Performance Battery SPPB; score range 0-12) were examined by cohort and participant characteristics (higher scores indicated better function). We assessed factors associated with discordance between scores (≥ 2 quartile difference) using multinomial logistic regression.
  
  APPEAL (N = 446; 81.4% Black) vs CLUES (N = 173; 41% Asian, 27.7% White, 23.1% Hispanic) participants had lower perceived PF (PROMIS
  
  -scores, 41.5 vs 47.9) and objective PF (SPPB scores, 9.0 vs 9.4). There was no difference after adjustment for disease activity and cumulative disease damage. Factors associated with lower perceived PF and objective PF across cohorts included oldest vs youngest age (
  
  -scores, 40.8 vs 47.4; SPPB scores, 8.9 vs 9.6), Black vs White race (
  
  -scores, 40.8 vs 45.6; SPPB scores, 8.9 vs 9.7), and higher vs lower disease activity (
  
  -scores, 38.1 vs 48.4; SPPB scores, 8.7 vs 9.6). Overall, 22.4% of participants had discordant scores; older age and higher disease activity were independently associated with lower risk of overestimating PF (objective score < perceived score).
  
  Our findings show that perceived and objective PF can vary considerably across SLE populations and patient characteristics. Perceived PF may not always reflect objective PF in SLE populations.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Lupus Erythematosus, Systemic
  • Female
  • Male
  • Middle Aged
  • Adult
  • Cohort Studies
  • Aged
  • Patient Reported Outcome Measures
  • Severity of Illness Index
  More +
• Keywords:
  • Physical Functional Performance
  • Lupus Erythematosus, Systemic
  • Epidemiology
  • Healthy Aging
• Source:
  The Journal of Rheumatology, 2026, v. 53, no. 6
• DOI:
  https://doi.org/10.3899/jrheum.2025-0857
• ISSN:
  0315-162X ; 1499-2752
• Pubmed ID:
  41539724
• Pubmed Central ID:
  PMC12818546
• Document Type:
  Text
• Funding:
  R01 AG061179/AG/NIA NIH HHSUnited States/ ; U01 DP006701/DP/NCCDPHP CDC HHSUnited States/ ; U01DP006698/ACL/ACL HHSUnited States/ ; U01DP006701/ACL/ACL HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  628-636 (17 pdf pages)
• Volume:
  53
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/260842/cdc_260842_DS1.pdf
• File Type:
  [PDF - 614.88 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f11b52a8a406fbcd3163ea8651d47ea47e5cc598888506d3c8167ea467877974b44936d9a9e9535f8ee1a89ea9dd669f8fd73eaab4ca56d4edd3aff678ed0b12