Risk of Spontaneous Abortion After MRNA COVID-19 Vaccination Received Just Prior to Or During Pregnancy: Complete Data From CDC COVID-19 Vaccine Pregnancy Registry.

Details

• Alternative Title:
  Vaccine, 2026, v. 76: Risk of Spontaneous Abortion After MRNA COVID-19 Vaccination Received Just Prior to Or During Pregnancy: Complete Data From CDC COVID-19 Vaccine Pregnancy Registry.
• Journal Article:
  Vaccine
• Personal Author:
  Madni, Sabrina A. ; Olson, Christine K. ; Zauche, Lauren Head ; Machefsky, Aliza ; Waters, Ansley V. ; Padathara-Mathew, Reji ; Okereke, Victoria ; Sharma, Andrea J.
• Description:
  Data on spontaneous abortion after COVID-19 vaccination during pregnancy are limited. We used data from the Centers for Disease Control and Prevention's COVID-19 Vaccine Pregnancy Registry (C19VPR) to assess risk of spontaneous abortion (SAB) among women receiving ≥1 mRNA COVID-19 vaccine up to 30 days before last menstrual period or during pregnancy. We calculated risk of SAB from 6 to 20 weeks' gestation using a fetuses-at-risk approach (n = 12,097). Pregnancies entered the risk pool at gestational age at vaccination. Risk of SAB in C19VPR was compared with pre-pandemic estimates. Cox proportional hazard models were used to compare risk by vaccine manufacturer. Cumulative risk of SAB was 10.79% (95%CI 10.01, 11.56). Risk of SAB among Moderna recipients was similar to Pfizer-BioNTech (adjusted hazard ratio 0.92; 95%CI 0.79, 1.07). Risk estimates of SAB were below or within pre-pandemic estimates. Generalizability may be limited due to homogeneity of the C19VPR cohort.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Pregnancy
  • Abortion, Spontaneous
  • Registries
  • COVID-19
  • Adult
  • COVID-19 Vaccines
  • Vaccination
  • Centers for Disease Control and Prevention, U.S.
  More +
• Keywords:
  • COVID-19
  • Pregnancy
  • Vaccination
  • Spontaneous abortion
• Source:
  Vaccine, 2026, v. 76
• DOI:
  https://doi.org/10.1016/j.vaccine.2026.128340
• ISSN:
  0264-410X ; 1873-2518
• Pubmed ID:
  41713234
• Pubmed Central ID:
  PMC12973310
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  128340 (12 pdf pages)
• Volume:
  76
• Download URL:
  https://stacks.cdc.gov/view/cdc/260775/cdc_260775_DS1.pdf
• File Type:
  [PDF - 251.12 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8ed55a46cfdda35db5ce1e2d4f7a23c27f788a50f9b48bd127e9ddd963727bb3362b435fb6fdecbf38dd7e85fc7083bf347dabdda8ae12f1f9ddd441fca89d2e