Celebrating Neuropathology's Contributions to Alzheimer's Disease Research Centers

Details

• Journal Article:
  Alzheimer's & Dementia
• Personal Author:
  Fischer, D. Luke ; Grinberg, Lea T. ; Ahrendsen, Jared T. ; Beach, Thomas G. ; Bieniek, Kevin F. ; Castellani, Rudolph J. ; Chkheidze, Rati ; Cobos, Inma ; Cohen, Mark ; Crary, John F. ; Dickson, Dennis W. ; Dugger, Brittany N. ; Dunlop, Sara R. ; Farrell, Kurt ; Ghetti, Bernardino ; Haeri, Mohammad ; Harrison, William ; Head, Elizabeth ; Hiniker, Annie ; Huang, Eric J. ; Huttner, Anita ; Jamshidi, Pouya ; Kapasi, Alifiya ; Keene, C. Dirk ; Kofler, Julia ; Latimer, Caitlin S. ; McKee, Ann C. ; Mente, Karin ; Miller, Michael B. ; Montine, Thomas J. ; Morris, Meaghan ; Murray, Melissa E. ; Nelson, Peter T. ; Newell, Kathy L. ; Perrin, Richard J. ; Ramani, Biswarathan ; Reichard, R. Ross ; Roy, Subhojit ; Schlachetzki, Johannes C. M. ; Seeley, William W. ; Serrano, Geidy E. ; Spina, Salvatore ; Teich, Andrew F. ; Wang, Shih-Hsiu J. ; Wisniewski, Thomas ; Lee, Edward B.
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• Description:
  Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for neurodegeneration research. Neuropathology has championed the key principles of proteinopathy, selective vulnerability, and stereotypic spread. Furthermore, neuropathologic studies advanced our understanding of ADRD prevalence, heterogeneity, clinical-pathological correlations, and genetic underpinnings, spurring biomarker development for target engagement and disease monitoring. Disease-modifying therapies for AD were inspired and informed by neuropathology. The neuropathology community is poised to refine diagnostics, leveraging digital pathology and integrating genetics and pathomics to enhance subtyping for novel precision medicine approaches. Despite some common misconceptions and logistical challenges, neuropathology continues to be a critical component of the ADRD research infrastructure, serving as a key bridge between allied basic and clinical sciences. Description provided by NIOSH
• Subjects:
  • Dementia
  • Neuropathology
  • Occupational Health
  • Safety
• Keywords:
  • Neuropathology
  • Neurological diseases
  • Genetic factors
  • Biomarkers
  • Diagnostic tests
  • Clinical diagnosis
  • Author Keywords: Alzheimer disease
  • dementia
  • neurodegenerative diseases
  • neuropathology
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• ISSN:
  1552-5260
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; Arizona ; Atlanta Region OSHA ; Birmingham Region OSHA ; California ; Chicago Region OSHA ; Dallas Region OSHA ; Florida ; Illinois ; Indiana ; Kansas ; Kansas City Region OSHA ; Missouri ; New York ; New York City Region OSHA ; North Carolina ; Ohio ; San Francisco Region OSHA ; Texas ; Connecticut ; Washington ; Pennsylvania ; Massachusetts ; Maryland ; Minnesota ; Boston Region OSHA ; Philadelphia Region OSHA
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• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  16 pdf pages
• Volume:
  21
• Issue:
  10
• NIOSHTIC Number:
  nn:20071729
• Citation:
  Alzheimers Dement 2025 Oct; 21(10):e70734
• Contact Point Address:
  Dr. Edward B. Lee, 612 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA
• Email:
  edward.lee@pennmedicine.upenn.edu
• Federal Fiscal Year:
  2026
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  2022/07/01
• End Date:
  2026/06/30
• Download URL:
  https://stacks.cdc.gov/view/cdc/259954/cdc_259954_DS1.pdf
• File Type:
  [PDF - 407.79 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f68ba848f9592fb6cbaa464c55f0e6b9fa99ed09ea1d51180c5941c6106c3c60a462ac37e690d8b18eb7b48d327934f499b26313964014941c53c394cf4ab41e