Lipidomics Profiling of Inflammatory and Specialized Pro-Resolving Mediators at the Junction of Inflammation-Resolution Transition in Mouse Lungs Exposed to Multiwalled Carbon Nanotubes [dataset]

Details

• Personal Author:
  Ma, Qiang ; Lim, Chol Seung ; LeBouf, Ryan F. ; Rimayi, Chengetayi C. ; Park, Ju-Hyeong
• Description:
  Multi-walled carbon nanotubes (MWCNTs) are new nanomaterials made of graphene sheets that role into multi-layer, concentric tubes. MWCNTs are airborne and resistant to natural and biological degradation. The potential that inhalation of MWCNTS at the workplace overtime causes lung injury and disease is a considerable health concern for exposed workers. Exposure to certain MWCNTs induces prominent acute inflammation with lung injury in laboratory animals. How fibrogenic MWCNTs instigate inflammation and how the interplay between inflammation and resolution of inflammation influences fibrotic development from exposure to MWCNTs have not been well understood. This study addressed these knowledge gaps by using a quantitative lipidomics approach to systematically profile inflammatory lipid mediators and specialized pro-resolving lipid mediators, major mediators of inflammation and resolution, respectively, at the junction of transition from acute inflammation to fibrotic progression in mouse lungs exposed to fibrogenic MWCNTs. Description provided by NIOSH
• Subjects:
  • Nanotubes, Carbon
  • Occupational Health
  • Respiratory System
  • Safety
• Keywords:
  • Multi-walled carbon nanotubes; MWCNT; Fibrosis; Immune reaction; Lipids; Lung tissue; Nanotoxicology; Inhalation; Pulmonary effects
• Source:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1121-2026-0, 2026 May; :dataset
• DOI:
  10.26616/NIOSHRD-1121-2026-0
• Document Type:
  Dataset
• Place as Subject:
  Philadelphia Region OSHA ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  3 pdf pages
• NIOSHTIC Number:
  nn:20071688
• Contact Point Address:
  Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, NIOSH, Morgantown, WV 26505, USA
• Email:
  qam1@cdc.gov
• CAS Registry Number:
  • Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2026
• Peer Reviewed:
  False
• Download URL:
  https://stacks.cdc.gov/view/cdc/259459/cdc_259459_DS1.pdf
• File Type:
  [PDF - 175.06 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:47eb232e8cae59467711e0cdf759ba8046de644f87552b21cb62050fef588b62c53ff0a15466582ce6a0c3bf95f02bcdc8a340c803019b6b84ceeafc13631f12