Pulmonary and Systemic Responses in Rats Following Intratracheal Instillation of Engineered Stone Dusts, Granite, and Silica [dataset]

Details

• Corporate Authors:
  National Institute of Occupational Safety and Health
• Description:
  This dataset contains information about how the lungs and bodies of laboratory rats responded after being exposed to dust from different types of engineered stone countertops, natural granite, and pure silica (a known hazardous material). Researchers looked at signs of inflammation, cell damage, and scarring (fibrosis) in the lungs, as well as changes in blood cell counts and chemistry, at different time points after a single exposure. The study found that engineered stone dust, especially types with high silica content, caused significant and lasting lung inflammation and damage, similar to the effects of pure silica. This helps us understand the potential health risks for workers who cut, grind, or install engineered stone countertops. Description provided by NIOSH
• Subjects:
  • Dust
  • Lung
  • Occupational Health
  • Respiratory System
  • Safety
  • Silicon Dioxide
• Keywords:
  • Crystalline silica; Stone grinders; Countertops; Stone products; Dust particles; Respirable dust; Toxicology; Pulmonary effects; Cytotoxicity; Lung fibrosis
• Source:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1120-2026-0, 2026 May; :dataset
• DOI:
  10.26616/NIOSHRD-1120-2026-0
• Document Type:
  Dataset
• Place as Subject:
  Philadelphia Region OSHA ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  2 pdf pages
• NIOSHTIC Number:
  nn:20071673
• Contact Point Address:
  Dr. W. Kyle Mandler Pathology and Physiology Branch Health Effects Laboratory Division National Institute for Occupational Safety and Health 1095 Willowdale Road, Morgantown, WV 26505 USA. Tel: (304) 285-6286
• Email:
  oex1@cdc.gov
• CAS Registry Number:
  • Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2026
• Peer Reviewed:
  False
• Download URL:
  https://stacks.cdc.gov/view/cdc/259445/cdc_259445_DS1.pdf
• File Type:
  [PDF - 142.20 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73d47338c1b3a0a4b64aff01c8f5dad49149e62a4ff8ec81407719a4a836e9c085688d1532f91ed043cd38512c25b8f1012641e642d80b9ae37eef2efb2d8517