Novel Chlamydia trachomatis Strains in Heterosexual Sex Partners, Indianapolis, Indiana, USA

Batteiger, Byron E.; Wan, Raymond; Williams, James A.; He, Linda; Ma, Arissa; Fortenberry, J. Dennis; Dean, Deborah

doi:10.3201/2011.140604

i

Novel Chlamydia trachomatis Strains in Heterosexual Sex Partners, Indianapolis, Indiana, USA

Supporting Files Public Domain

Nov 2014
By Batteiger, Byron E. ; Wan, Raymond ; Williams, James A. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Batteiger, Byron E. ; Wan, Raymond ; Williams, James A. ; He, Linda ; Ma, Arissa ; Fortenberry, J. Dennis ; Dean, Deborah
Description:

Chlamydia trachomatis causes a high number of sexually transmitted infections worldwide, but reproducible and precise strain typing to link partners is lacking. We evaluated multilocus sequence typing (MLST) for this purpose by detecting sequence types (STs) concordant for the ompA genotype, a single-locus typing standard. We tested samples collected during April 2000-October 2003 from members of established heterosexual partnerships (dyads) in the Indianapolis, Indiana, USA, area who self-reported being coital partners within the previous 30 days. C. trachomatis DNA from 28 dyads was tested by MLST; sequences were aligned and analyzed for ST and phylogenetic relationships. MLST detected 9 C. trachomatis STs, 4 unique to Indianapolis; STs were identical within each dyad. Thirteen unique strains were identified; 9 (32%) dyads harbored novel recombinant strains that phylogenetically clustered with strains comprising the recombinants. The high rate of novel C. trachomatis recombinants identified supports the use of MLST for transmission and strain diversity studies among at-risk populations.
Subjects:

Adolescent Adult Chlamydia Infections Chlamydia Trachomatis Female Genes, Bacterial Genotype Heterosexuality Humans Male Multilocus Sequence Typing Phylogeny Recombination, Genetic Research Sexual Partners Young Adult
Source:

Emerg Infect Dis. 20(11):1841-1847.
Document Type:

Journal Article
Place as Subject:

Indianapolis, IN
Location:

North America
Volume:

20
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:cc969251cfbf09397068801fca9e0b0f9ba69b269740a5c71a3b69ee954073af
Download URL:

https://stacks.cdc.gov/view/cdc/25937/cdc_25937_DS1.pdf
File Type:

[PDF - 613.44 KB ]

File Language:

English

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