Use of JYNNEOS (Smallpox and Mpox Vaccine, Live, Nonreplicating) for Persons Aged ≥ 18 Years at Risk for Mpox During an Mpox Outbreak: Recommendations of the Advisory Committee on Immunization Practices - United States, 2023

Details

• Personal Author:
  Rao, Agam K. ; Minhaj, Faisal S. ; Carter, Rosalind J. ; Duffy, Jonathan ; Satheshkumar, Panayampalli S. ; Delaney, Kevin P. ; Quilter, Laura A. S. ; Kachur, Rachel E. ; McLean, Catherine A. ; Moulia, Danielle L. ; Kuhar, David T. ; de Perio, Marie A. ; Spicknall, Ian H. ; Bell, Beth P. ; Sánchez, Pablo J. ; Hutson, Christina L. ; Cohn, Amanda C.
• Description:
  What is already known about this topic? CDC provides interim vaccination guidance for self-limited mpox outbreaks; however, a clade IIb outbreak that began in 2022 has had a protracted course, and the risk for U.S. mpox outbreaks has increased. What is added by this report? In 2023, the Advisory Committee on Immunization Practices (ACIP) recommended JYNNEOS (smallpox and mpox vaccine, live, nonreplicating) for persons aged ≥18 years who are at risk for mpox during any mpox outbreak and who are at risk for mpox during the ongoing clade IIb outbreak. What are the implications for public health practice? ACIP recommends JYNNEOS during outbreaks to improve vaccination coverage and limit the scope of outbreaks. As of 2025, the clade IIb outbreak has continued; the need for vaccinating persons at risk will be reassessed as the outbreak evolves. [Description provided by NIOSH]
• Subjects:
  Mpox, Monkeypox Occupational Health Safety Smallpox Vaccines Vaccines Virus Diseases
• Keywords:
  Mpox; Monkeypox virus; Vaccines; Viral diseases; Infectious diseases; Infection control; Recommendations; Disease prevention
• Source:
  MMWR 2025 Jun; 74(22):385-392
• Series:
  Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Atlanta Region [OSHA] ; Chicago Region [OSHA] ; Georgia ; Ohio ; San Francisco Region [OSHA] ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 pdf pages
• Volume:
  74
• Issue:
  22
• NIOSHTIC Number:
  nn:20071562
• Email:
  ige4@cdc.gov
• Federal Fiscal Year:
  2025
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:55592752ffdf965a099bac89a19228901703f1b26711f05ce1ace19d438f75f7c9602698b9c8bc882d0c1e7c7512f11ec9f7ea7d6ade1d235436766f038b57c1
• Download URL:
  https://stacks.cdc.gov/view/cdc/259337/cdc_259337_DS1.pdf
• File Type:
  [PDF - 147.99 KB ]