A New Approach for Simultaneous Measurement of Aerosol Respiratory Deposition and Its Chemical Composition: Health Risk Assessment of Metal Engineered Nanomaterials in Consumer Spray Aerosols

Details

• Journal Article:
  International Journal of Hygiene and Environmental Health
• Personal Author:
  Lee, Jinho ; Su, Wei-Chung
• Description:
  Background: Conventional methods for studying aerosol deposition face limitations when applied to aerosols with irregular shapes and diverse physical properties. Objective: This study aimed to develop the MALDA (Mobile Aerosol Lung Deposition Apparatus)-MOUDI tandem system to simultaneously estimate the size-specific deposition fraction of aerosols and their chemical constituents. Using this innovative approach, we investigated the respiratory deposition of aerosols generated from selected consumer spray products and evaluated the inhalation risks of engineered nanomaterials (ENMs), specifically metals, in these aerosols. Methods: Aerosols were generated from two common types of consumer spray products-trigger and propellant sprays. The size-segregated respiratory deposition fraction and mass proportions of target metals in the aerosols were measured. Occupational exposure scenarios were then designed to estimate the non-cancer and cancer risks associated with inhalation of ENMs (metals) in these aerosols. Results: The MALDA-MOUDI tandem system was successfully developed and validated. Results demonstrated that the non-cancer and cancer risks of inhaled metals due to occupational exposure to the target spray aerosols were below established safety thresholds. Significance: The MALDA-MOUDI tandem system provides an innovative and systematic approach to assess size-specific aerosol deposition in major human airway regions. This method can be applied to broader environmental and occupational aerosol exposure research to evaluate health risks from toxic substances in aerosols. Findings from this study also offer valuable insights for environmental and occupational health research and propose an improved method for health risk assessment.
• Subjects:
  Aerosols Metals Nanostructures Occupational Exposure Occupational Health Risk Assessment Safety
• Keywords:
  Aerosols; Aerosol particles; Particle aerodynamics; Inhalation studies; Risk assessment; Nanomaterials; Occupational exposure; Metals; Sprays
• Source:
  Int J Hyg Environ Health 2025 Jun; 267:114588
• ISSN:
  1438-4639
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Texas ; Dallas Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  14 pdf pages
• Volume:
  267
• NIOSHTIC Number:
  nn:20071440
• Contact Point Address:
  Jinho Lee, Boston University, School of Public Health, Department of Environmental Science, Talbot W Building, 715 Albany Street, Boston, MA, 02118, USA
• Email:
  jinholee@bu.edu
• Federal Fiscal Year:
  2025
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:66b36e538fddb60cfb264d8fea636fc3c0dade82539d306808996534690065e8bda8c78ed54ade8b5a5cebe0e6810ed9fabdba06443eb89666e5f9e8ed79dd30
• Download URL:
  https://stacks.cdc.gov/view/cdc/259039/cdc_259039_DS1.pdf
• File Type:
  [PDF - 7.52 MB ]