Weak Sensitizers May Be Associated with CD80 Polymorphisms: Implications for Systemic Contact Dermatitis

Details

• Journal Article:
  JID Innovations
• Personal Author:
  Nedorost, Susan ; Zhang, Ge ; Fekedulegn, Desta B. ; Fluharty, Kara L. ; Wang, Wei ; Frye, Bonnie ; Baron, Elma ; Zug, Kathryn ; Yucesoy, Berran
• Description:
  Chronic irritant dermatitis predisposes to Th2 skewed allergic contact dermatitis. Chronic hand dermatitis due to wet work or childhood- onset irritant flexural dermatitis (AD) is associated with sensitization to weak or non-sensitizing antigens as defined by the local lymph node (LLN) assay. In about 15% of these patients, ingestion of allergens results in systemic contact dermatitis, defined as recall dermatitis at previous sites. In this large exploratory study, not even known associations (e.g. IL4R and AD) survived correction for tests of multiple associations. As such, we analyzed for associations using p<0.005 combined with OR >1.8 or <0.5. We found that positive patch tests to weak allergens were common with 3 polymorphisms of CD80. CD80 is a co-stimulatory molecule on several cell types including innate lymphoid group 2 cells (ILC2). ILC2 presentation may bypass education in the local lymph node, explaining the association of antigens classified as non-sensitizers in LLN assay with CD80, and the absence of symptoms of immediate type hypersensitivity in many of these patients. Food handlers with hand dermatitis and patients with atopic dermatitis should be patch tested to allergens in foods (e.g. propylene glycol, vanillin, nickel, cobalt, and chromates) and instructed on dietary restriction of these allergens.
• Subjects:
  Dermatitis, Contact Food Hypersensitivity Hypersensitivity Occupational Health Safety
• Keywords:
  Author Keywords: Allergic Contact Dermatitis; Atopic Dermatitis; Food Allergy; Innate Lymphoid Cells; Systemic Contact Dermatitis Contact Dermatitis; Immune Reaction; Sensitizers; Sensitization; Allergic Reactions; Allergens; Lymph Nodes; Food;
• Source:
  JID Innov 2025 Jul; 5(4):100382
• ISSN:
  2667-0267
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; West Virginia ; Maryland ; New Hampshire ; Chicago Region [OSHA] ; Philadelphia Region [OSHA] ; Boston Region [OSHA}
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 pdf pages
• Volume:
  5
• NIOSHTIC Number:
  nn:20071435
• Contact Point Address:
  Susan Nedorost, Department of Dermatology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA
• Email:
  stn@case.edu
• Federal Fiscal Year:
  2025
• NORA Priority Area:
  Public Safety
• Peer Reviewed:
  True
• Resource Number:
  3927ZJYJ
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:428b87c86505e490d9b808d11a68b520eb96a076bc600b9f99d057a059f68108a2586848e1a2e567171a277462051e39e12fe884cdf93b3b21d4deb0eff9407f
• Download URL:
  https://stacks.cdc.gov/view/cdc/259034/cdc_259034_DS1.pdf
• File Type:
  [PDF - 423.87 KB ]