Gastroesophageal Disease Risk and Inhalational Exposure a Systematic Review and Meta-Analysis

Details

• Journal Article:
  Scientific Reports
• Personal Author:
  Kim, Daniel Hyun ; Podury, Sanjiti ; Fallahzadeh, Aida ; Mahmoodi, Tara ; Kwon, Sophia ; Grunig, Gabriele ; Liu, Mengling ; Nolan, Anna
• Description:
  Environmental exposure-associated diseases, particularly in the context of rising air pollution and inhalant use, are an active area of research. Our group is dedicated to the study of exposure-related inflammation and its downstream adverse health effects. While many studies have focused on the impact of environmental exposures on respiratory sequelae, there is growing evidence of the involvement of other systems including gastrointestinal. This systematic review provides updates on the associations between inhalation exposures and the risk of upper gastrointestinal disease. Primary search identified N = 764 PubMed and N = 1,036 Web of Science studies, of which N = 111 met eligibility criteria. Our systematic review and meta-analysis showed significant associations between inhalational exposures (cigarette smoking, waterpipe smoking, and particulate matter) and upper gastrointestinal diseases. The pooled estimate of esophagitis was 1.32 (95% confidence interval [CI], 1.06-1.65; I2:86%), gastroesophageal reflux disease was 1.71 (1.14-2.55; I²:94%), peptic ulcer disease was 1.21 (1.03-1.43; I2:93%), esophageal cancer was 1.83 (1.54-2.18; I2:73%), and gastric cancer was 1.71 (1.39-2.10; I2:73%). However, the pooled estimate for Barrett's esophagus was 0.93 (0.65-1.34; I2:76%), indicating no significant association. Sensitivity analyses confirmed these findings. Risk of bias assessment showed most studies were of good quality. Our findings emphasize the impact of inhalational exposures on gastrointestinal disease risk, highlighting the need for further research to better understand this interaction and targeted public health interventions.
• Subjects:
  Air Pollution Gastroesophageal Reflux Gastrointestinal Tract Occupational Health Particulate Matter Safety
• Keywords:
  Author Keywords: Systematic Review; Environmental Exposure; Smoking; Particulate Matter; Aerodigestive Disease; Meta-analysis Environmental Exposure; Air Pollution; Systematic Reviews; Gastrointestinal System Disorders; Gastroesophageal Reflux Disease; GERD; Inhalation; Smoking; Particulates;
• Source:
  Sci Rep 2025 Jul; 15:22581
• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; New York City Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  23 pdf pages
• Volume:
  15
• NIOSHTIC Number:
  nn:20071419
• Contact Point Address:
  Anna Nolan, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2025
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20210701
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0b600f0c4345faf473c94976a2aab18a992c47bcbcc1f29e664cb7d3f6354e58672ba87d005f960e2a9ee7d8057596483da2df77a35fe67d6338a2e866c7fa69
• Download URL:
  https://stacks.cdc.gov/view/cdc/259018/cdc_259018_DS1.pdf
• File Type:
  [PDF - 3.97 MB ]