Epigenetic Study of the Long-Term Effects of Gulf War Illness

Details

• Journal Article:
  Frontiers in Genetics
• Personal Author:
  Jones, B. C. ; O'Callaghan, James P. ; Ashbrook, D. G. ; Lu, L. ; Prins, P. ; Zhao, W. ; Mozhui, K.
• Description:
  Introduction: Gulf War Illness is a chronic multisymptomatic disorder that affects as many as 25-35% of the military personnel who were sent to the Persian Gulf war in 1991. The illness has many debilitating symptoms, including cognitive problems, gastrointestinal symptoms, and musculoskeletal pain. Those so afflicted have been sick for more than 30 years and, therefore, it has become imperative to understand the etiology of Gulf War Illness and then produce treatments to ease the symptoms. We hypothesized that the length of the disease was reflected in epigenetic modification of possibly several genes related to the symptoms. Methods: We subjected male and female mice from 11 BXD strains to combined corticosterone and the sarin surrogate, diisopropylfluorophosphate, to emulate the physiological stress of war and the potential exposures to organophosphate pesticides and nerve agent in theater. Three hundred days after treatment, we used Methyl-CpG-binding domain sequencing (MBD-seq) to assay genome-wide methylation. Results: The analysis revealed 20 methylated genes, notably Eif2b5, that regulates myelin production. Discussion: Loss of myelin with accompanying musculoskeletal pain is a major symptom of Gulf War Illness. Our work demonstrates multiple genes were methylated by exposure to organophosphates and glucocorticoids. These genes point to biochemical mechanisms that may be targets for therapeutic intervention.
• Subjects:
  Epigenomics Occupational Health Persian Gulf Syndrome Safety Sarin
• Keywords:
  Author Keywords: MBD-seq; Forward Genetcs; QTL; Loci Of Quantitative Traits; BXD Mice; Neuroinflammation Military Personnel; Immune Reaction; Genetic Factors; Genes; Gene Expression; Physiological Stress; Sarin;
• Source:
  Front Genet 2025 Jun; 16:1553410
• ISSN:
  1664-8021
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Tennessee ; West Virginia ; Birmingham Region [OSHA] ; Philadelphia Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 pdf pages
• Volume:
  16
• NIOSHTIC Number:
  nn:20071410
• Contact Point Address:
  B. C. Jones, Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States
• Email:
  bjone129@uthsc.edu
• Federal Fiscal Year:
  2025
• Peer Reviewed:
  True
• Resource Number:
  493906RC
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6df9ec04719a614e43823d6d000983ba8a30c4e0e1dd41af0ce1f9d7c62bb5db97ca4b479676d24606ffb5b95175a5872f7bf04f8d4b7e895175ee2b75727347
• Download URL:
  https://stacks.cdc.gov/view/cdc/259010/cdc_259010_DS1.pdf
• File Type:
  [PDF - 1.94 MB ]