Dietary Sources of Methylated Arsenic Species in Urine of the United States Population, NHANES 2003–2010

Details

• Alternative Title:
  PLoS One
• Personal Author:
  deCastro, B. Rey ; Caldwell, Kathleen L. ; Jones, Robert L. ; Blount, Benjamin C. ; Pan, Yi ; Ward, Cynthia ; Mortensen, Mary E.
• Description:
  Background
  
  Arsenic is an ubiquitous element linked to carcinogenicity, neurotoxicity, as well as adverse respiratory, gastrointestinal, hepatic, and dermal health effects.
  
  Objective
  
  Identify dietary sources of speciated arsenic: monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA).
  
  Methods
  
  Age-stratified, sample-weighted regression of NHANES (National Health and Nutrition Examination Survey) 2003–2010 data (∼8,300 participants ≥6 years old) characterized the association between urinary arsenic species and the additional mass consumed of USDA-standardized food groups (24-hour dietary recall data), controlling for potential confounders.
  
  Results
  
  For all arsenic species, the rank-order of age strata for median urinary molar concentration was children 6–11 years > adults 20–84 years > adolescents 12–19 years, and for all age strata, the rank-order was DMA > MMA. Median urinary molar concentrations of methylated arsenic species ranged from 0.56 to 3.52 µmol/mol creatinine. Statistically significant increases in urinary arsenic species were associated with increased consumption of: fish (DMA); fruits (DMA, MMA); grain products (DMA, MMA); legumes, nuts, seeds (DMA); meat, poultry (DMA); rice (DMA, MMA); rice cakes/crackers (DMA, MMA); and sugars, sweets, beverages (MMA). And, for adults, rice beverage/milk (DMA, MMA). In addition, based on US (United States) median and 90th percentile consumption rates of each food group, exposure from the following food groups was highlighted: fish; fruits; grain products; legumes, nuts, seeds; meat, poultry; and sugars, sweets, beverages.
  
  Conclusions
  
  In a nationally representative sample of the US civilian, noninstitutionalized population, fish (adults), rice (children), and rice cakes/crackers (adolescents) had the largest associations with urinary DMA. For MMA, rice beverage/milk (adults) and rice cakes/crackers (children, adolescents) had the largest associations.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Arsenicals Cacodylic Acid Carcinogens Child Diet Environmental Exposure Female Humans Male Middle Aged Nutrition Surveys Young Adult

  More +
• Source:
  PLoS One. 2014; 9(9).
• Document Type:
  Journal Article
• Name as Subject:
  National Health and Nutrition Examination Survey (U.S.)
• Place as Subject:
  United States
• Volume:
  9
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e2b04f72fdfbf8e3860bcd58dd15b256c55c81d2fdf8f2d40904f304fa78597d
• Download URL:
  https://stacks.cdc.gov/view/cdc/25565/cdc_25565_DS1.pdf
• File Type:
  [PDF - 319.25 KB ]