Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Zhang, Hai-Lin ; Zhang, Yu-Zhen ; Yang, Wei-Hong ; Tao, Xiao-Yan ; Li, Hao ; Ding, Ji-Chao ; Feng, Yun ; Yang, Du-Juan ; Zhang, Juan ; He, Jiang ; Shen, Xin-Xin ; Wang, Li-Hua ; Zhang, Yun-Zhi ; Song, Miao ; Tang, Qing
  More +
• Description:
  Yunnan Province in China borders 3 countries (Vietnam, Laos, and Myanmar) in Southeast Asia. In the 1980s, a large-scale rabies epidemic occurred in this province, which subsided by the late 1990s. However, 3 human cases of rabies in 2000 indicated reemergence of the disease in 1 county. In 2012, rabies was detected in 77 counties; 663 persons died of rabies during this new epidemic. Fifty two rabies virus strains obtained during 2008-2012 were identified and analyzed phylogenetically by sequencing the nucleoprotein gene. Of the 4 clades identified, clades YN-A and YN-C were closely related to strains from neighboring provinces, and clade YN-B was closely related to strains from Southeast Asia, but formed a distinct branch. Rabies virus diversity might be attributed to dog movements among counties, provinces, and neighboring countries. These findings suggest that Yunnan Province is a focal point for spread of rabies between Southeast Asia and China.
• Subjects:
  • Synopsis
  • Animals
  • Antigens, Viral/immunology
  • Communicable Diseases, Emerging/epidemiology
  • Dog Diseases/virology
  • Dogs
  • Female
  • Genes, Viral
  • Genetic Variation
  • Geography, Medical
  More +
• Source:
  Emerg Infect Dis. 20(9):1433-1442.
• Document Type:
  Journal Article
• Place as Subject:
  Asia, Southeastern ; China
• Location:
  Asia
• Volume:
  20
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/25466/cdc_25466_DS1.pdf
• File Type:
  [PDF - 888.05 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8dc204657db0bf123f41493723f5836ec965d1a7ffa9d51d97caff8c8b9483dd