Infant and Environmental Exposures to Thimerosal and Neuropsychological Outcomes at Ages 7 to 10 Years: Technical Report Volume II

Details

• Personal Author:
  Price, Cristofer ; Goodson, Barbara ; Stewart, Gerrie
• Corporate Authors:
  Abt Associates Inc. ; Centers for Disease Control and Prevention (CDC) (U.S.). Immunization Safety Office
• Description:
  CDC conducted the Infant and Environmental Exposures to Thimerosal and Neuropsychological Outcomes at Ages 7 to 10 Years study to investigate possible associations between prenatal and early childhood exposure to thimerosal-containing vaccines and/or immunoglobulins and deficits in neuropsychological functioning .Thimerosal is a preservative that contains ethyl mercury and is used in some vaccines and immunoglobulins. This study was not designed to assess possible association between thimerosal and autism. This study was designed to improve upon previous studies that assessed the possible association between ethyl mercury exposure from thimerosal-containing vaccines and neuropsychological functioning including an objective measurement of neuropsychological functioning. These improvements reduced the potential for study biases. The study was further strengthened by engaging a panel of independent external consultants to advise on the study design, selection of the neuropsychological test battery, interpretation of results, and editing of the draft manuscript. The consultants have expertise in the fields of toxicology, epidemiology, biostatistics, vaccine safety, and also included a representative from the autism advocacy community. The external consultants provided their individual input into the study protocol and the analysis plan. The study evaluated 1,047 children between the ages of 7 to 10 years who received vaccines during the 1990's when thimerosal was used as a preservative in many childhood vaccines. The study used a retrospective cohort design. Computerized medical records were used to select a sample of children with a wide range of exposures from thimerosal-containing vaccines and immunoglobulins during infancy. Each child's level of exposure to ethyl mercury was determined through a review of electronic immunization registries, medical records, personal immunization records, and parent interviews. Each child was then administered a series of standardized neuropsychological tests in a clinical setting at ages 7 to 10 years.
• Subjects:
  Ethylmercury Compounds Mercury Methylmercury Compounds Safety Thimerosal Vaccines
• Keywords:
  Vaccine safety
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  United States
• Rights:
  Public Domain
• CIO:
  Immunization Safety Office
• Topic:
  Injury, Violence, & Safety
• Location:
  North America
• Pages in Document:
  173 pdf pages
• Volume:
  2
• CAS Registry Number:
  Thimerosal (CAS RN 54-64-8) ; Mercury (CAS RN 7439-97-6) ; Ethylmercury (CAS RN 21687-36-5) ; Methylmercury(1+) (CAS RN 22967-92-6)
• Collection(s):
  Infectious Diseases
• Main Document Checksum:
  urn:sha-512:b5e17d368d36c34b7c1c13541b3535973eeccaa0836acdd55d100abe39a11eea1f566e997472446f768bf464b089b423bb72921831e12031173524f6314d2f61
• Download URL:
  https://stacks.cdc.gov/view/cdc/253141/cdc_253141_DS1.pdf
• File Type:
  [PDF - 9.50 MB ]