Molecular clustering analysis of blood biomarkers in World Trade Center exposed community members with persistent lower respiratory symptoms.

Details

• Personal Author:
  Berger KI ; Cotrina-Vidal ML ; Doo K ; Durmus N ; Goldring R ; Grunig G ; Liu M ; Lu Y ; Pehlivan S ; Reibman J ; Shao Y ; Wang Y ; Zhang Y
• Description:
  The destruction of the World Trade Center (WTC) on September 11, 2001 (9/11) released large amounts of toxic dusts and fumes into the air that exposed many community members who lived and/or worked in the local area. Many community members, defined as WTC survivors by the federal government, developed lower respiratory symptoms (LRS). We previously reported the persistence of these symptoms in patients with normal spirometry despite treatment with inhaled corticosteroids and/or long-acting bronchodilators. This report expands upon our study of this group with the goal to identify molecular markers associated with exposure and heterogeneity in WTC survivors with LRS using a selected plasma biomarker approach. Samples from WTC survivors with LRS (n = 73, WTCS) and samples from healthy control participants of the NYU Bellevue Asthma Registry (NYUBAR, n = 55) were compared. WTCS provided information regarding WTC dust exposure intensity. Hierarchical clustering of the linear biomarker data identified two clusters within WTCS and two clusters within NYUBAR controls. Comparison of the WTCS clusters showed that one cluster had significantly increased levels of circulating matrix metalloproteinases (MMP1, 2, 3, 8, 12, 13), soluble inflammatory receptors (receptor for advanced glycation end-products-RAGE, Interleukin-1 receptor antagonist (IL-1RA), suppression of tumorigenicity (ST)2, triggering receptor expressed on myeloid cells (TREM)1, IL-6Ralpha, tumor necrosis factor (TNF)RI, TNFRII), and chemokines (IL-8, CC chemokine ligand-CCL17). Furthermore, this WTCS cluster was associated with WTC exposure variables, ash at work, and the participant category workers; but not with the exposure variable WTC dust cloud at 9/11. A comparison of WTC exposure categorial variables identified that chemokines (CCL17, CCL11), circulating receptors (RAGE, TREM1), MMPs (MMP3, MMP12), and vascular markers (Angiogenin, vascular cell adhesion molecule-VCAM1) significantly increased in the more exposed groups. Circulating biomarkers of remodeling and inflammation identified clusters within WTCS and were associated with WTC exposure. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Biomarkers Dust Hazardous Substances Immune System Occupational Health Respiratory Tract Diseases Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: World Trade Center Exposure; Plasma Biomarkers; Lower Respiratory Symptoms; Irritant Induced Asthma; Persistent Respiratory Symptoms Following Exposures; September 11 2001 Disaster; Molecular Biomarkers WTC; World Trade Center; Dust Exposure; Toxic Materials; Respiratory System Disorders; Asthma; Molecular Epidemiology; Biomarkers; Immune System;
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  California ; New York ; OSHA Region 2 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  13
• NIOSHTIC Number:
  nn:20065726
• Citation:
  Int J Environ Res Public Health 2022 Jul; 19(13):8102
• Contact Point Address:
  Gabriele Grunig, Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
• Email:
  grunig01@nyu.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:922f45d04933c8559fe0979d0b6f5633b62bf1bbd9af81c95749168da60a9a7ff4d3130e07b97cd8e728a4754ea768accf73b54adf7336a45a0f9a86929b5140
• Download URL:
  https://stacks.cdc.gov/view/cdc/249528/cdc_249528_DS1.pdf
• File Type:
  [PDF - 1.93 MB ]