COPD in smoking and non-smoking community members exposed to the World Trade Center dust and fumes.

Details

• Personal Author:
  Baba RY ; Berger KI ; Goldring RM ; Kazeros A ; Liu M ; Reibman J ; Rosen R ; Shao Y ; Zhang Y
• Description:
  Background: The characteristics of community members exposed to World Trade Center (WTC) dust and fumes with Chronic Obstructive Pulmonary Disease (COPD) can provide insight into mechanisms of airflow obstruction in response to an environmental insult, with potential implications for interventions. Methods: We performed a baseline assessment of respiratory symptoms, spirometry, small airway lung function measures using respiratory impulse oscillometry (IOS), and blood biomarkers. COPD was defined by the 2019 GOLD criteria for COPD. Patients in the WTC Environmental Health Center with <5 or ≥ 5 pack year smoking history were classified as nonsmoker-COPD (ns-COPD) or smoker-COPD (sm-COPD), respectively. Main results: Between August 2005 and March 2018, 467 of the 3430 evaluated patients (13.6%) fit criteria for COPD. Among patients with COPD, 248 (53.1%) were ns-COPD. Patients with ns-COPD had measures of large airway function (FEV1) and small airway measures (R5-20, AX) that were less abnormal than those with sm-COPD. More ns-COPD compared to sm-COPD had a bronchodilator (BD) response measured by spirometry (24 vs. 14%, p = 0.008) or by IOS (36 vs. 21%, p = 0.002). Blood eosinophils did not differ between ns-COPD and sm-COPD, but blood neutrophils were higher in sm-COPD compared to ns-COPD (p < 0.001). Those with sm-COPD were more likely to be WTC local residents than ns-COPD (p = 0.007). Conclusions: Spirometry findings and small airway measures, as well as inflammatory markers, differed between patients with ns-COPD and sm-COPD. These findings suggest potential for differing mechanisms of airway injury in patients with WTC environmental exposures and have potential therapeutic implications. [Description provided by NIOSH]
• Subjects:
  Air Movements Air Pollutants, Occupational Asthma Asthma, Occupational Biomarkers Blood Community Health Services Dust Environmental Exposure Lung Men Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks Women

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• Keywords:
  Author Keywords: Chronic Obstructive Pulmonary Disease; New York City; September 11 Terrorist Attacks; World Trade Center; Air Pollutants; Asthma; Dust; Lung/Physiology; Oscillometry; Spirometry World Trade Center; WTC; Disaster Sites; Dust Exposure; Dust Inhalation; Smoke Inhalation; Community Health; Surveillance; Asthma; Respirable Dust; Respiratory Diseases; Airborne Dusts; Health Effects; COPD; Chronic Obstructive Pulmonary Disease; Air Flow; Environmental Exposure; Intervention; Risk Assessment; Spirometry; Lung Function; Oscillography; Blood; Biomarkers; Humans; Men; Women; Statistical Analysis;
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  7
• NIOSHTIC Number:
  nn:20064972
• Citation:
  Int J Environ Res Public Health 2022 Apr; 19(7):4249
• Contact Point Address:
  Joan Reibman, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
• Email:
  Joan.Reibman@nyulangone.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3619356caa8979b1f127c7e8603a3cb1b1ffd6f4facdf250d036a80e0aaab6945f3c26aa85a204276fffd2fbade7d7f016ab9e1e894412032e2cc266f7c79be8
• Download URL:
  https://stacks.cdc.gov/view/cdc/248823/cdc_248823_DS1.pdf
• File Type:
  [PDF - 620.23 KB ]