The Effects of Ambient Ozone Exposure on the Dispersion of an Inhaled NaCL Aerosol Bolus in Exercising Adults

Details

• Personal Author:
  Jaques PA ; Kinney PL ; Lippmann, Morton ; Thurston GD
• Description:
  The aerosol bolus dispersion technique (ABDT) is a respiratory maneuver previously developed to indicate damage in small airways based on changes in the lung's effects on aerosol dispersion during respiration. In the ABDT, a bolus of submicrometer particles is injected into a subject's deep lung tidal breath of filtered air. It has been shown to be a sensitive measure of small airway functional changes after ozone chamber exposures (Am. Rev. Respir. Dis. 141(4): A72, 1990). However, we have now developed a NaCl based ABDT, which provides one of the safest possible test aerosols, and thereby broadens the subject group base in which the ABDT can be routinely employed. As part of a larger ambient human pollution exposure study conducted for the U.S. EPA on Governors Island, NYC, NY, we conducted a study to assess the sensitivity and utility of the NaCl ABDT method in the field, and to test for small airway functional effects as a result of ambient ozone exposures. Nonsmoking healthy male joggers, who were Coast Guard personnel. were tested on multiple occasions between early July and late September 1993 for NaCl aerosol bolus dispersion, both before and after running. Real-time measurements of ambient ozone ranged between 10 to 145 ppb during the runs (with exercise times of about 2.0 minutes). During the ABDT maneuver, a 300 ml bolus of NaCl aerosol (da = 0.4 micro m) was injected into a 2 liter tidal breath (0.67 liters/sec) at a 700 ml penetration depth. The dispersion effects are expressed as a change in: the first three moments of a normal distribution; the bolus volume half-width; particle deposition; and, the concentration peak-height. Each parameter is examined via regression as a function of ozone exposure for each individual subject and also collectively for all subjects. The field results are compared with past lab O3 controlled exposure results. Conclusions are drawn regarding both the usefulness of this NaCl ABDT and the implied effects of ozone on small airways of the lung. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollution Lung Occupational Health Ozone Particulate Matter Respiratory System Safety
• Keywords:
  Aerosol Particles Air Pollution Breathing Health Effects Humans Inhalation Lung Function Particulates
• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  6
• Issue:
  2
• NIOSHTIC Number:
  nn:20060130
• Citation:
  Epidemiology 1995 Mar; 6(2)(Suppl):S23
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6) ; Sodium chloride (CAS RN 7647-14-5)
• Federal Fiscal Year:
  1995
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  False
• Start Date:
  19920701
• Source Full Name:
  Epidemiology
• Supplement:
  Supplement
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a9381f5976bea1628540288226c8e2216cd1c042a9e850e64225e0fa9930fb36eeb0f6489b348d99ebff7687d6064fe396ae4ccbbbeb2cb43dd1146cd4782960
• Download URL:
  https://stacks.cdc.gov/view/cdc/224139/cdc_224139_DS1.pdf
• File Type:
  [PDF - 197.31 KB ]