Pulmonary toxicity and gene expression changes in response to whole-body inhalation exposure to multi-walled carbon nanotubes in rats (dataset).

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Nanomaterials represent a new class of materials with numerous industrial applications. Considering the projected increase in the production and use of nanomaterials, a corresponding increase in occupational exposure to nanomaterials and their resulting adverse health effects may be anticipated among workers. There is substantial evidence in the literature, based on cell culture and animal studies, supporting the potential toxicity and detrimental health effects associated with exposure to nanomaterials. Intervention and/or prevention of adverse health effects associated with occupational exposure to toxic nanomaterials is a concern for health providers and regulatory and non-regulatory government agencies as the use of nanomaterials expand. A key element in the intervention and/or prevention of the adverse health effects associated with occupational exposure to toxic nanomaterials is a clear understanding of the molecular mechanisms underlying the pulmonary toxicity induced by nanomaterials. Due to its physicochemical and mechanical properties, multi-walled carbon nanotubes (MWCNT) have found many industrial applications. There is potential for human exposure to MWCNT or products that contain MWCNT both during the production and use of the materials that contain MWCNT. The objectives of the current study were to investigate MWCNT-induced lung toxicity and the molecular mechanisms underlying that toxicity. A rat inhalation exposure model was employed to determine the lung toxicity induced by MWCNT. Global gene expression profiles in the lung and blood were conducted to determine the molecular mechanisms underlying MWCNT-induced lung toxicity. [Description provided by NIOSH]
• Subjects:
  Animals Lung Occupational Health Respiratory System Safety
• Keywords:
  Nanomaterials; MWCNT; Multi-walled carbon nanotubes; Animal studies; Gene expression; Pulmonary effects; Toxic effects; Lung tissue
• DOI:
  https://doi.org/10.26616/NIOSHRD-1039-2022-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20065444
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1039-2022-0, 2022 Jun; :dataset
• Contact Point Address:
  Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1000 Frederick Lane, Morgantown, WV 26508. Tel: (304)285-6240
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Pulmonary toxicity and gene expression changes in response to whole-body inhalation exposure to multi-walled carbon nanotubes in rats
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0cf4b7c781c02dc12c184aeadd11a8bdd2a517e4a959b85189b636c55836d8bbdec367bce44ab861fd3a75fb3e1a2cc669ee07df24414dcbe6c14190803326b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/249439/cdc_249439_DS1.pdf
• File Type:
  [PDF - 146.59 KB ]