Alveolar Surface Area, Surface Tension, & Compliances of Enzyme Treated Cat Lungs

Details

• Personal Author:
  Fisher MJ ; Weber KC
• Description:
  Cats were given single or multiple intratracheal injections of papain (3 to 30 mg. total) and/or phospholipase-C (0.2 to 3 mg total). The alveolar surface area and area surface tension relationships for the enzyme treated cat lungs (obtained from gas and liquid pressure-volume data one week to 4 months after the last injection) were not significantly different from those of the control cats, indicating the absence of any gross tissue destruction by the enzymes. This indicates the cat lung is highly resistant to papain induced emphysema in contradistinction to the rapid induction of emphysema in the rat lung by papain (Cats were given single or multiple intratrachael injections of papain (3 to 30 mg. total) and/or phospholipase-C (0.2 to 3 mg total). The alveolar surface area and area surface tension relationships for the enzyme treated cat lungs (obtained from gas and liquid pressure-volume data one week to 4 months after the last injection) were not significantly different from those of the control cats, indicating the absence of any gross tissue destruction by the enzymes. This indicates the cat lung is highly resistant to papain induced emphysema in contradistinction to the rapid induction of emphysema in the rat lung by papain (Cross, P., Arch. Environ. 11: 50-58, 1965). This observation was supported by histological data from cat and rat lungs. Compliances of the papain treated cat lungs were increased during gas deflation at small lung volumes and decreased during gas and liquid deflations at large lung volumes. Phospholipase-C had only a slight effect on lung compliances. Lung radiographs revealed that within 1/2 hour after the intratrachael injections of papain, a pneumonic infiltrate was present within the terminal bronchioles and alveolar spaces indicating some lung changes. The lung radiographs returned to normal within 5 days.). This observation was supported by histological data from cat and rat lungs. Compliances of the papain treated cat lungs were increased during gas deflation at small lung volumes and decreased during gas and liquid deflations at large lung volumes. Phospholipase-C had only a slight effect on lung compliances. Lung radiographs revealed that within 1/2 hour after the intratrachael injections of papain, a pneumonic infiltrate was present within the terminal bronchioles and alveolar spaces indicating some lung changes. The lung radiographs returned to normal within 5 days. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal Studies Laboratory Animals Lung Disease Lung Disorders Lung Tissue Respiratory Function Respiratory System Disorders
• ISSN:
  0014-9446
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Alabama ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALFORD - Appalachian Laboratory for Occupational Respiratory Disease
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  31
• Issue:
  2
• NIOSHTIC Number:
  nn:20050890
• Citation:
  Fed Proc 1972 Mar-Apr; 31(2):336Abs
• Contact Point Address:
  K.. C. Weber, ALFORD, NIOSH, USPHS, HEW, Morgantown, WV, 26506
• Federal Fiscal Year:
  1972
• Peer Reviewed:
  False
• Source Full Name:
  Federation Proceedings
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:46d983422ae4a8f2efa50b1f1e866da832d0af39e32e803ff858cfa178418bb540600e053f12f9b8f344c0a7e5654cba853ad73f84bcd727f9fbf0d78944f54a
• Download URL:
  https://stacks.cdc.gov/view/cdc/211081/cdc_211081_DS1.pdf
• File Type:
  [PDF - 2.04 MB ]