Saturated fat intake is associated with lung function in individuals with airflow obstruction: results from NHANES 2007-2012.

Details

• Personal Author:
  Alam M ; Bailey K ; Cornell K ; Hanson C ; LeVan TD ; Lyden E ; Nordgren TM ; Wood L
• Description:
  Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007-2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV1), FEV1, forced vital capacity (FVC), FEV1/FVC ratio, percent predicted FEV1 and percent predicted FVC. Multivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV1/FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV1 (beta = -126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC (beta = -165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (beta = -3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV1/FVC ratio and percent predicted FEV1. It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes. [Description provided by NIOSH]
• Subjects:
  Diet Lipids Lung Occupational Health Respiratory System Safety
• Keywords:
  Author Keywords: COPD; Saturated Fat; Lipids; Lung Function; NHANES Dietary Effects; Lung Function; Fatty Acids; Nutrition; Chronic Obstructive Pulmonary Disease; COPD; Lipids; Diet;
• ISSN:
  2072-6643
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; Nebraska ; OSHA Region 7 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  2
• NIOSHTIC Number:
  nn:20065189
• Citation:
  Nutrients 2019 Feb; 11(2):317
• Contact Point Address:
  Corrine Hanson, Medical Nutrition Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE 68198, USA
• Email:
  ckhanson@unmc.edu
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Nutrients
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:192a299a89811a177b7987fca339abec62102cbc1603975341aadad9b38d1a9b03d16c9958e648060d5ffe57186cf52c366113fde1230cdb7bfdc2ed4325c6eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/249364/cdc_249364_DS1.pdf
• File Type:
  [PDF - 299.20 KB ]