Menstrual cycle characteristics as determinants of plasma concentrations of perfluoroalkyl substances (PFASs) in the Norwegian Mother and Child Cohort (MoBa study).

Details

• Personal Author:
  Haug LS ; Impinen A ; Longnecker MP ; Papadopoulou E ; Sabaredzovic A ; Singer AB ; Whitworth KW
• Description:
  Introduction: Perfluoroalkyl substances (PFASs) are fluorinated organic compounds that have been used in a variety of industrial and consumer applications. Menstruation is implicated as a possible route of elimination for PFASs in women. The overall purpose of this study was to examine menstrual cycle characteristics as determinants of plasma PFAS concentrations in women. Methods: Our study sample consisted of 1977 pregnant women from the Norwegian Mother and Child Cohort (MoBa) study. The women were asked about menstrual cycle regularity in the year before the pregnancy and typical menstrual cycle length as well as other demographic and reproductive characteristics in a questionnaire completed during the pregnancy. Blood samples were collected around 17-18 weeks gestation and PFAS concentrations were measured in plasma. We examined the association between menstrual cycle characteristics and seven PFASs (perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), and perfluorooctane sulfonate (PFOS)) using multiple linear regression, adjusted for age, pre-pregnancy body mass index, smoking, education, income, parity, oral contraceptive (OC) use, inter-pregnancy interval, and breastfeeding duration. Results: Irregular cycles were not associated with PFAS concentrations. Overall, we found no evidence of associations between menstrual cycle length and PFAS concentrations. In subgroup analyses we found some evidence, among parous women, of decreased PFHpS and PFOS with short menstrual cycles; we also found, among recent OC users (in the 12 months before the questionnaire) increased PFNA and PFUnDA with long cycle length. Limitations of our study include misclassification of menstrual cycle characteristics, small sample sizes in the sub-group analyses, and a lack of information on duration and volume of menses. Conclusions: In the entire study sample, we found little evidence of menstrual cycle characteristics as determinants of PFAS concentrations. However, we observed some associations between cycle length and PFAS concentrations with some select PFAS compounds in subgroup analyses. [Description provided by NIOSH]
• Subjects:
  Blood Cohort Studies Hematologic Tests Occupational Health Pregnancy Safety Surveys And Questionnaires Urogenital Diseases Urogenital System Women
• Keywords:
  Author Keywords: Perfluoroalkyl Substances; Menstrual; Irregularity; Cycle Length; MoBa Women; Pregnancy; Cohort Studies; Menstrual Disorders; Reproductive System Disorders; Questionnaires; Blood Samples; Blood Plasma; Per- And Polyfluoroalkyl Substances; PFAS;
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  78-85
• Volume:
  166
• NIOSHTIC Number:
  nn:20065185
• Citation:
  Environ Res 2018 Oct; 166:78-85
• Contact Point Address:
  Alison B. Singer, Department of Epidemiology, Gillings School of Global Public Health, CB #7435, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
• Email:
  alison_singer@unc.edu
• CAS Registry Number:
  Perfluorodecanoic acid (CAS RN 335-76-2) ; Perfluoroheptanesulfonic acid (CAS RN 375-92-8) ; Perfluorohexanesulfonic acid (CAS RN 355-46-4) ; Perfluorononanoic acid (CAS RN 375-95-1) ; Perfluorooctanesulfonic acid (CAS RN 1763-23-1) ; Perfluorooctanoic acid (CAS RN 335-67-1) ; Perfluoroundecanoic acid (CAS RN 2058-94-8)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6f645fd550fef7de667ad4e2ae6cdd274e982fb15c0216b8027de57d2ea6a0495a0337d4b13e924c5155397c22dcfb36606e9fee4138de7dd5ec3b0aef57ceaf
• Download URL:
  https://stacks.cdc.gov/view/cdc/249362/cdc_249362_DS1.pdf
• File Type:
  [PDF - 263.02 KB ]