t(14;18) Translocations in Dioxin-Exposed Workers [2022]

Details

• Personal Author:
  Baccarelli AA ; Bartell S ; Dardynskaia I ; Dardynskiy O ; Hirt C ; Hryhorczuk D ; Ruestow P ; Steenland, Kyle ; Turner W ; Zvinchuk O
• Description:
  Objective: To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations. Methods: A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral blood mononuclear cells in 218 former chemical plant workers and 150 population controls. Results: The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls. There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD and TEQ. Conclusion: Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations. [Description provided by NIOSH]
• Subjects:
  Blood Dioxins Environmental Exposure Genetics Manufacturing And Industrial Facilities Neoplasms Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Skin Diseases

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• Keywords:
  Author Keywords: Chloracne; Dioxin; T(14;18) Translocations Occupational Exposure; Dioxins; Lymphatic Cancer; Chemical Industry Workers; Gene Expression; Genes; Gene Regulation; Cell Signaling; Workers; Blood Cells; Chemicals; Chemical Industry Workers; TCDD; Dioxin; 2,3,7,8-Tetrachloro-dibenzo-p-dioxin; Exposure Levels; Risk Factors;
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Illinois ; New York ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  331-339
• Volume:
  64
• Issue:
  4
• NIOSHTIC Number:
  nn:20065072
• Citation:
  J Occup Environ Med 2022 Apr; 64(4):331-339
• Contact Point Address:
  Daniel Hryhorczuk, MD, MPH, Division of Environmental and Occupational Health Sciences, University of Illinois School of Public Health, 1603 W. Taylor Street, Chicago, IL 60612
• Email:
  dhryhorc@uic.edu
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6)
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20080801
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1bbf3915a259a7e7e46b750a6a8930a8b8ad6f438ed5fdea6a6a76d8ed0a2179ec0aab9d192d219f18315386e28565066a2a985b9223612d716409d3c0ed9fd4
• Download URL:
  https://stacks.cdc.gov/view/cdc/249318/cdc_249318_DS1.pdf
• File Type:
  [PDF - 671.16 KB ]