Remote smartphone monitoring of Parkinson's disease and individual response to therapy.

Details

• Personal Author:
  Adams J ; Bloem BR ; Bot BM ; Chaibub Neto E ; Dorsey ER ; Elson M ; Goldman SM ; Kellen MR ; Kieburtz K ; Klein A ; Little MA ; Mangravite LM ; Omberg L ; Perumal TM ; Pratap A ; Schneider R ; Suver C ; Tanner CM ; Tarolli C ; Tediarjo A ; Trister AD ; Wilbanks J
• Description:
  Remote health assessments that gather real-world data (RWD) outside clinic settings require a clear understanding of appropriate methods for data collection, quality assessment, analysis and interpretation. Here we examine the performance and limitations of smartphones in collecting RWD in the remote mPower observational study of Parkinson's disease (PD). Within the first 6 months of study commencement, 960 participants had enrolled and performed at least five self-administered active PD symptom assessments (speeded tapping, gait/balance, phonation or memory). Task performance, especially speeded tapping, was predictive of self-reported PD status (area under the receiver operating characteristic curve (AUC) = 0.8) and correlated with in-clinic evaluation of disease severity (r = 0.71; P < 1.8 × 10-6) when compared with motor Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Although remote assessment requires careful consideration for accurate interpretation of RWD, our results support the use of smartphones and wearables in objective and personalized disease assessments. [Description provided by NIOSH]
• Subjects:
  Electrical Equipment And Supplies Occupational Health Safety Women
• Keywords:
  Parkinsonism; Diseases; Monitoring systems; Electronic devices; Humans; Women; Task performance
• ISSN:
  1087-0156
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  480-487
• Volume:
  40
• Issue:
  4
• NIOSHTIC Number:
  nn:20064991
• Citation:
  Nat Biotechnol 2022 Apr; 40(4):480-487
• Contact Point Address:
  Larsson Omberg, Sage Bionetworks, Seattle, WA
• Email:
  larsson.omberg@sagebionetworks.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Nature Biotechnology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c90b89092b137c16c6e77818059c4f53553d602291dcff2d9c9b44ce891e141f4d134ada91986644726ab29f0f1f4edf389a7968a1f89e04a8d6b0d555e6d654
• Download URL:
  https://stacks.cdc.gov/view/cdc/249298/cdc_249298_DS1.pdf
• File Type:
  [PDF - 3.17 MB ]