Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment.

Details

• Personal Author:
  Bromet EJ ; Carr MA ; Clouston SAP ; Gandy S ; Haung C ; Kritikos M ; Kuan P-F ; Lucchini RG ; Luft BJ ; Pellecchia AC ; Sano M ; Santiago-Michels S ; Vaska P
• Description:
  Prior research has demonstrated high levels of cognitive and physical functional impairments in World Trade Center (WTC) responders. A follow-up neuroimaging study identified changes to white matter connectivity within the cerebellum in responders with cognitive impairment (CI). In the first study to examine cerebellar cortical thickness in WTC responders with CI, we fielded a structural magnetic resonance imaging protocol. WTC responders (N = 99) participated in a structural magnetic resonance imaging (MRI) study, of whom 48 had CI. Participants with CI did not differ demographically or by intracranial volume when compared to cognitively unimpaired participants. MRIs were processed using the CERES imaging pipeline; bilateral cortical thickness in 12 cerebellar lobules was reported. Analyses were completed comparing mean cerebellar cortical thickness across groups. Lobules were examined to determine the location and functional correlates of reduced cerebellar cortical thickness. Multivariable-adjusted analyses accounted for the false discovery rate. Mean cerebellar cortical thickness was reduced by 0.17 mm in responders with CI. Decrements in cerebellar cortical thickness were symmetric and located in the Cerebellar Crus (I and II), and in Lobules IV, VI, VIIb, VIIIa, VIIIb, and IX. Cerebellar cortical thickness was associated with episodic memory, response speed, and tandem balance. WTC responders with CI had evidence of reduced cerebellar cortical thickness that was present across lobules in a pattern unique to this cohort. [Description provided by NIOSH]
• Subjects:
  Aging Emergency Responders Environmental Exposure Epidemiology Mental Disorders Mental Health Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  World Trade Center; WTC; First responders; Emergency responders; Cognitive function; Mental disorders; Epidemiology; Age groups; Exposure levels; Risk factors; Etiology; Neurological disorders; Magnetic resonance imaging; MRI
• ISSN:
  2158-3188
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  Florida ; New York ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• NIOSHTIC Number:
  nn:20064791
• Citation:
  Transl Psychiatry 2022 Mar; 12:107
• Contact Point Address:
  Sean A.P. Clouston, Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook, Stony Brook, NY, USA
• Email:
  sean.clouston@stonybrookmedicine.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Translational Psychiatry
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f21de9f1331e821703cf83691f45971bdfd579fd37a095cbee96ae4d44fd3660501cb2923e68efe6f6797166fbb546220b533c0e13a126efe215821422b1fce7
• Download URL:
  https://stacks.cdc.gov/view/cdc/249239/cdc_249239_DS1.pdf
• File Type:
  [PDF - 1011.48 KB ]