Reduced Cortical Thickness in World Trade Center Responders with Cognitive Impairment

Details

• Personal Author:
  Bromet EJ ; Carr MA ; Clouston SAP ; DeLorenzo C ; Deri Y ; Diminich E ; Gandy S ; Horton M ; Kritikos M ; Lucchini RG ; Luft BJ ; Pellecchia AC ; Sano M ; Santiago-Michels S ; Tang C
• Description:
  Introduction: This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods: WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region-based and surface-based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region-based measures were also compared to published norms. Results: Participants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface-based analyses revealed reduced CTX across frontal, temporal, and parietal lobes when adjusting for multiple comparisons. Both CI and unimpaired WTC groups had reduced CTX in the entorhinal and temporal cortices compared to published normative data. Discussion: Results from the first structural magnetic resonance imaging study in WTC responders identified reduced CTX consistent with a neurodegenerative disease of unknown etiology. [Description provided by NIOSH]
• Subjects:
  Aging Emergency Responders Environmental Exposure Epidemiology Mental Disorders Mental Health Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Age Groups Author Keywords: World Trade Center Responders Cognitive Function Cognitive Impairment Cortical Thickness Emergency Responders Etiology Exposure Levels First Responders Mental Disorders Neurological Disorders Risk Factors World Trade Center WTC

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• ISSN:
  2352-8729
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  1
• NIOSHTIC Number:
  nn:20060489
• Citation:
  Alzheimers Dement Diagn Assess Dis Monit 2020 Jul; 12(1):e12059
• Contact Point Address:
  Dr. Sean A.P.Clouston, Program in Public Health, 101 Nichols Rd., Health Sciences Center, #3-071, Stony Brook University, Stony Brook, NY 11794-8338
• Email:
  sean.clouston@stonybrookmedicine.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:78946d0b2be9e002c96419484e0e144a980834f61570787e157817828368aa2054691748b49940aa0b12200ed475d135f1a9b4e00e65ffd919ee7ebd7dba0bb0
• Download URL:
  https://stacks.cdc.gov/view/cdc/224364/cdc_224364_DS1.pdf
• File Type:
  [PDF - 1.95 MB ]