Dermal exposure to the immunomodulatory antimicrobial chemical triclosan alters the skin barrier integrity and microbiome in mice (dataset).

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Triclosan is an antimicrobial chemical used in healthcare settings that can be absorbed through the skin. Exposure to triclosan has been positively associated with food and aeroallergy and asthma exacerbation in humans and, although not directly sensitizing, has been demonstrated to augment the allergic response in a mouse model of asthma. The skin barrier and microbiome are thought to play important roles in mediating inflammation and allergy and disruptions may contribute to development of allergic disease. To investigate potential connections of the skin barrier and microbiome with immune responses to triclosan, SKH1 mice were dermally exposed to triclosan (0.5-2%) or vehicle for up to 7 consecutive days. [Description provided by NIOSH]
• Subjects:
  Animals Hypersensitivity Immune System Occupational Health Safety Skin
• Keywords:
  Dermal exposures; Skin exposure; Animal studies; Antimicrobials; Skin irritants; Immunological tests; Immune reaction; Allergic reactions; Allergies
• DOI:
  https://doi.org/10.26616/NIOSHRD-1034-2022-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20064898
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1034-2022-0, 2022 Apr; :dataset
• Contact Point Address:
  Allergy and Clinical Immunology Branch (ACIB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV. Phone: 304.285.6024
• CAS Registry Number:
  Triclosan (CAS RN 3380-34-5)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Healthcare and Social Assistance ; Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  Dermal exposure to the immunomodulatory antimicrobial chemical triclosan alters the skin barrier integrity and microbiome in mice
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b5a39566b1b6c54199ca1818451d4ff929d1bf0932530f2ed79db1bfcd65ba24afbd0f916dccd082cb2a14c5ef2cf5f0d6781fc51e8ec236cd2db0d35224ada9
• Download URL:
  https://stacks.cdc.gov/view/cdc/248842/cdc_248842_DS1.pdf
• File Type:
  [PDF - 120.31 KB ]