Restraint Stress Applied Prior to Chemical Sensitization Modulates the Development of Allergic Contact Dermatitis Differently than Restraint Prior to Challenge

Flint MS; Johnson, Elizabeth A.; Miller DB; Tinkle SS; Valosen JM

i

Restraint Stress Applied Prior to Chemical Sensitization Modulates the Development of Allergic Contact Dermatitis Differently than Restraint Prior to Challenge

Public Domain

2001/02/01
By Flint MS ; Johnson, Elizabeth A. ; Miller DB ; ...

Details

Personal Author:

Flint MS ; Johnson, Elizabeth A. ; Miller DB ; Tinkle SS ; Valosen JM
Description:

BALB/c mice were sensitized and challenged on the skin with the contact sensitizer, dinitroflourobenzene. Acute restraint applied before sensitization diminished, whereas restraint administered before challenge enhanced, chemical-induced ear swelling and leukocytic infiltration in the dermis. Administration of RU486, a glucocorticoid receptor antagonist, partially reversed restraint modulation of the ear swelling response in both restraint paradigms. Restraint did not modulate significantly the concentration of TNF-alpha and IL-1 beta in ear tissue homogenates. These data show that acute restraint modulates cutaneous sensitization differently than challenge, but the changes are not reflected in TNF-alpha or IL-l beta production. [Description provided by NIOSH]
Subjects:

Animals Hypersensitivity Immune System Laboratories Occupational Health Safety Skin Skin Diseases
Keywords:

Allergic Dermatitis Animal Studies Author Keywords: Stress Contact Dermatitis Corticosterone Cytokine Immune Reaction Immune System Laboratory Animals Leukocytes RU486 Sensitization
ISSN:

0165-5728
Document Type:

Text
Genre:

Journal Article
Place as Subject:

OSHA Region 3 ; West Virginia
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Division:

HELD - Health Effects Laboratory Division
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

72-80
Volume:

113
Issue:

1
NIOSHTIC Number:

nn:20020672
Citation:

J Neuroimmunol 2001 Feb; 113(1):72-80
Email:

sft3@cdc.gov
Federal Fiscal Year:

2001
Peer Reviewed:

True
Source Full Name:

Journal of Neuroimmunology
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:839b9a202bad91ad5647961b3438d2c6ddf0343e2afd638f40c5138b83a39a0befbd10709a3451bc3aa198717a7526dfe37e3172a7bd5b0c0db6bddc0adedc99
Download URL:

https://stacks.cdc.gov/view/cdc/198353/cdc_198353_DS1.pdf
File Type:

[PDF - 1.09 MB ]

ON THIS PAGE

Details

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.