Continuous NHANES survey data for environmental ambient and occupational hazard identification - feasibility and preliminary findings for osteoporosis and kidney disease.

Details

• Personal Author:
  An Y ; Park RM
• Description:
  The Continuous NHANES Survey provides detailed health and environmental chemical burden information on the U.S. population. As of 2012, there were data for 72,000 participants. Based on single biomarker determinations, cumulative burdens were estimated. Because age distributions would differ comparing ambient environmental and occupational exposures, a procedure to distinguish ambient from likely occupational exposures was applied. Associations are reported for osteoporosis and kidney disease-related outcomes with cadmium, lead, and other metals. Cumulative cadmium burden (from blood cadmium, ambient and occupational) was a strong predictor of bone fracture risk and ambient tungsten also had a positive association. Cumulative lead (ambient and occupational) had a negative ("protective") association with fractures as did mercury (occupational). Bone mineral density was statistically significant and similarly predicted by metal exposures. Kidney disease was significantly associated with cumulative lead burdens from both the estimated ambient and occupational sources and with ambient blood cadmium but was most strongly associated with cumulative occupational uranium burden. Systolic blood pressure statistically significantly increased with cumulative ambient and occupational lead (blood) burden and with ambient cadmium and cobalt. Diastolic blood pressure was significantly associated with several cadmium and cobalt metrics along with ambient and occupational cumulative burdens for lead. For environmental substances with burden half-lives measured in years, NHANES offers opportunities for hypothesis generation and confirmation. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Environmental Pollution Epidemiology Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Chemical Body Burden; Lead; Osteoporosis; Renal Insufficiency; Surveillance; Uranium Risk Assessment; Environmental Exposure; Occupational Exposure; Bone Disorders; Kidney Disorders; Environmental Pollution; Surveillance; Epidemiology;
• ISSN:
  1545-9624
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  489-499
• Volume:
  19
• Issue:
  8
• NIOSHTIC Number:
  nn:20065553
• Citation:
  J Occup Environ Hyg 2022 Aug; 19(8):489-499
• Contact Point Address:
  Robert M. Park, National Institute for Occupational Safety and Health, 1228 Schirmer Ave, Cincinnati, OH 45230, USA
• Email:
  rhpark9@gmail.com
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:791713252f9ed4af9a21298ae155383d330bf4361c5b0779af592478ecc25590e51f612213e125a43f98b12257834f4bca0eb56b0459e3156556713a427f8236
• Download URL:
  https://stacks.cdc.gov/view/cdc/248822/cdc_248822_DS1.pdf
• File Type:
  [PDF - 1.50 MB ]