Characteristics of women with lung adenocarcinoma in the World Trade Center Environmental Health Center.

Details

• Personal Author:
  Arslan AA ; Durmus N ; Lu Y ; Pehlivan S ; Reibman J ; Shao Y ; Shum E ; Zhang Y
• Description:
  The destruction of the World Trade Center towers on 11 September 2001 exposed local residents, workers, and individuals in the area (Survivors) to dust and fumes that included known and suspected carcinogens. Given the potential for inhalation of toxic substances and the long latency after exposure, the incidence of lung cancer is expected to increase in WTC-exposed individuals. We describe the characteristics of women WTC Survivors with lung adenocarcinoma who were enrolled in the WTC Environmental Health Center (WTC EHC) between May 2002 and July 2021. A total of 173 women in WTC EHC had a diagnosis of any type of lung cancer, representing 10% of all cancers in women. Most of the lung cancers (87%) were non-small cell carcinomas, with adenocarcinoma (77%) being the most common subtype. Nearly half (46%) of these patients were exposed to dust clouds on 11 September 2001. Race and ethnicity varied by smoking status, as follows: 44% of Asian women compared with 29% of non-Hispanic White women were never-smokers (p < 0.001). There was no significant difference between the pathologic characteristics of adenocarcinomas between never and ever smokers. We also summarize EGFR, ALK, KRAS, ROS-1 and BRAF mutation status stratified by smoking, race and ethnicity. The identification of a relatively high proportion of women never-smokers with lung cancer warrants further investigation into the role of WTC dust exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Dust Environmental Exposure Epidemiology Lung Lung Diseases Neoplasms Occupational Health Race Factors Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks Smokers Women

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• Keywords:
  Author Keywords: September 11; WTC Environmental Health Center; World Trade Center; WTC; Biomarker; Lung Adenocarcinoma; Lung Cancer; Smoking; Women World Trade Center; WTC; Women; Environmental Exposure; Epidemiology; Fumes; Lung Cancer; Adenocarcinomas; Dust Exposure; Racial Factors; Smoking; Biomarkers;
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  13
• NIOSHTIC Number:
  nn:20065576
• Citation:
  Int J Environ Res Public Health 2022 Jul; 19(13):7618
• Contact Point Address:
  Joan Reibman, Division of Pulmonary Medicine, Department of Medicine, New York University Langone Health, New York, NY 10016
• Email:
  joan.reibman@nyulangone.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  NYC Health + Hospitals (H+H): NYC H+H Data Center
• Peer Reviewed:
  True
• Start Date:
  20170401
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20210331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ded083be8a184c5951def85d3fee0fa2694ab0efcd63005b54c4674009c001a546a494f68b474413eaa6fbf791381c22a47e1d44f204e43f7cd0137c08e6f258
• Download URL:
  https://stacks.cdc.gov/view/cdc/248790/cdc_248790_DS1.pdf
• File Type:
  [PDF - 459.62 KB ]