Urinary total arsenic and arsenic methylation capacity in pregnancy and gestational diabetes mellitus: a case-control study.

Details

• Personal Author:
  Chen W-J ; Davis EM ; Garwe T ; Goodman JR ; Hwang J ; Janitz AE ; Peck JD ; Robledo C ; Stoner JA ; Xu C
• Description:
  Previous studies suggest arsenic exposure may increase the risk of gestational diabetes mellitus (GDM). However, prior assessments of total arsenic concentrations have not distinguished between toxic and nontoxic species. Our study aimed to investigate the relationships between inorganic arsenic exposure, arsenic methylation capacity, and GDM. Sixty-four cases of GDM and 237 controls were analyzed for urinary concentrations of inorganic arsenic species and their metabolites (arsenite (As3), arsenate (As5), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA)), and organic forms of arsenic. Inorganic arsenic exposure was defined as the sum of inorganic and methylated arsenic species (iSumAs). Methylation capacity indices were calculated as the percentage of inorganic arsenic species [iAs% = (As3 + As5)/iSumAs, MMA% = MMA/iSumAs, and DMA% = DMA/iSumAs]. Multivariable logistic regression was performed to evaluate the association between inorganic arsenic exposure, methylation capacity indices, and GDM. We did not observe evidence of a positive association between iSumAs and GDM. However, women with GDM had an increased odds of inefficient methylation capacity when comparing the highest and lowest tertiles of iAs% (adjusted odds ratio (aOR) = 1.48, 95% CI 0.58-3.77) and MMA% (aOR = 1.95 (95% CI 0.81-4.70) and a reduced odds of efficient methylation capacity as indicated by DMA% (aOR = 0.62 (95% CI 0.25-1.52), though the confidence intervals included the null value. While the observed associations with arsenic methylation indices were imprecise and warrant cautious interpretation, the direction and magnitude of the relative measures reflected a pattern of lower detoxification of inorganic arsenic exposures among women with GDM. [Description provided by NIOSH]
• Subjects:
  Arsenic Blood Endocrine System Environmental Exposure Epidemiology Hematologic Diseases Inorganic Chemicals Occupational Health Pregnancy Safety Urine

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• Keywords:
  Arsenic; Pregnancy; Blood Sugar Disorders; Environmental Exposure; Endocrine Disruptors; Epidemiology; Urine Chemistry; Author Keywords: Arsenic; Inorganic Arsenic; Methylation; Gestational Diabetes
• ISSN:
  0045-6535
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Kentucky ; Ohio ; Oklahoma ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  271
• NIOSHTIC Number:
  nn:20064986
• Citation:
  Chemosphere 2021 May; 271:129828
• Contact Point Address:
  Wei-Jen Chen, Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, 801 N.E. 13th Street, CHB 381, Oklahoma City, OK, 73104, USA
• Email:
  weijen-chen@ouhsc.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Chemosphere
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:01d06b7393d4cc9d1017ed6b53ff30cf7d484f51231f1efbbe581faf8df0a33194fb6aaf2f8b3e7d91c38d0b2d831c51d22bb6c3aab5356393c6f26c75500fc7
• Download URL:
  https://stacks.cdc.gov/view/cdc/248705/cdc_248705_DS1.pdf
• File Type:
  [PDF - 335.25 KB ]