A high docosahexaenoic acid diet alters the lung inflammatory response to acute dust exposure.

Details

• Personal Author:
  Baack ML ; Dominguez EC ; Guardado S ; Heires AJ ; Larsen TD ; Nordgren TM ; Pavlik J ; Romberger DJ ; Sisson JH
• Description:
  Agricultural workers are at risk for the development of acute and chronic lung diseases due to their exposure to organic agricultural dusts. A diet intervention using the omega-3 fatty acid docosahexaenoic acid (DHA) has been shown to be an effective therapeutic approach for alleviating a dust-induced inflammatory response. We thus hypothesized a high-DHA diet would alter the dust-induced inflammatory response through the increased production of specialized pro-resolving mediators (SPMs). Mice were pre-treated with a DHA-rich diet 4 weeks before being intranasally challenged with a single dose of an extract made from dust collected from a concentrated swine feeding operation (HDE). This omega-3-fatty-acid-rich diet led to reduced arachidonic acid levels in the blood, enhanced macrophage recruitment, and increased the production of the DHA-derived SPM Resolvin D1 (RvD1) in the lung following HDE exposure. An assessment of transcript-level changes in the immune response demonstrated significant differences in immune pathway activation and alterations of numerous macrophage-associated genes among HDE-challenged mice fed a high DHA diet. Our data indicate that consuming a DHA-rich diet leads to the enhanced production of SPMs during an acute inflammatory challenge to dust, supporting a role for dietary DHA supplementation as a potential therapeutic strategy for reducing dust-induced lung inflammation. [Description provided by NIOSH]
• Subjects:
  Agriculture Dust Immune System Lung Occupational Health Respiratory System Safety
• Keywords:
  Agriculture; Agricultural Workers; Organic Dusts; Dietary Effects; Immune Reaction; Lung Function; Fatty Acids; Author Keywords: Omega-3 Fatty Acids; Docosahexaenoic Acid; DHA; Organic Dust; Lung Inflammation; Specialized Pro-resolving Mediators; SPM
• ISSN:
  2072-6643
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; Nebraska ; OSHA Region 7 ; OSHA Region 8 ; OSHA Region 9 ; South Dakota
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  8
• NIOSHTIC Number:
  nn:20065112
• Citation:
  Nutrients 2020 Aug; 12(8):2334
• Contact Point Address:
  Tara M. Nordgren, Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA 92521, USA
• Email:
  tmnordgren@gmail.com
• CAS Registry Number:
  Docosahexaenoic acid (CAS RN 25167-62-8)
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Nutrients
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d0db860ce01b4d7373849984abf653ca7bb6dec3e99489580a0ec276f23e8cfef6e9b425bd3fb38e43c5204551aeb58efe49f1581867ba811f8bdb7c0552ae52
• Download URL:
  https://stacks.cdc.gov/view/cdc/248609/cdc_248609_DS1.pdf
• File Type:
  [PDF - 3.32 MB ]