Allergic fungal rhinosinusitis diagnosis, management, associated conditions, pathophysiology, and future directions: summary of a multidisciplinary workshop.

Details

• Personal Author:
  Azar A ; Cahill KN ; Cho D-Y ; Corry D ; Croston TL ; Damask C ; Ebert CS Jr. ; Edwards T ; Freeman AF ; Javer A ; Khoury P ; Kim J ; Koval M ; Levy JM ; Luong AU ; McCoul ED ; Mims JW ; Peters A ; Piccirillo JF ; Ramonell RP ; Roland LT ; Samarasinghe A ; Schleimer RP ; Smith-Davidson P ; Spec A ; Wechsler ME ; Wise SK
• Description:
  Allergic fungal rhinosinusitis (AFRS) is a unique endotype of chronic rhinosinusitis with nasal polyps (CRSwNP). Despite high recurrence rates and often more severe presenting signs compared with other subtypes of CRSwNP, research dedicated to AFRS has been lacking. Diagnostic criteria are outdated, the mechanistic relationship of AFRS to other associated diseases is unclear, and the pathophysiology of disease and risk factors for recurrence have not been well studied. In December 2023, a multidisciplinary group of rhinologists, otolaryngologists, pulmonologists, allergists, immunologists, scientists, and infectious disease experts met at the National Institute of Health to discuss unmet needs for future AFRS research and care, including patient management, diagnostic criteria, severity, pathophysiology, and related conditions. A summary of these clinical and associated research discussions is included below. [Description provided by NIOSH]
• Subjects:
  Diagnosis Fungi Hypersensitivity Immune System Nose Occupational Health Pathology Safety Sense Organs
• Keywords:
  Allergic Disorders; Allergies; Fungal Diseases; Fungi; Nasal Cavity; Nasal Disorders; Clinical Diagnosis; Pathology; Immune Reaction; Author Keywords: Allergic Sinusitis; Allergic Fungal Sinusitis; Chronic Rhinosinusitis; Fungal Sinusitis; Invasive Fungal Sinusitis; Nasal Polyps
• ISSN:
  2042-6976
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; Atlanta Region [OSHA] ; Birmingham Region [OSHA] ; Chicago Region [OSHA] ; Dallas Region [OSHA] ; Florida ; Georgia ; Illinois ; Louisiana ; Maryland ; North Carolina ; Pennsylvania ; Philadelphia Region [OSHA] ; Tennessee ; Texas ; West Virginia ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070948
• Citation:
  Int Forum Allergy Rhino 2025 May; :[Epub ahead of print]
• Contact Point Address:
  Lauren T. Roland, Department of Otolaryngology, Washington University in St Louis, St Louis, Missouri, USA
• Email:
  lauren.tashima.roland@gmail.com
• Federal Fiscal Year:
  2025
• Peer Reviewed:
  True
• Source Full Name:
  International Forum of Allergy & Rhinology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248343/cdc_248343_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]