The Role of Platelets in the Pathogenesis of Viral Hemorrhagic Fevers

Details

• Alternative Title:
  PLoS Negl Trop Dis
• Personal Author:
  Zapata, Juan C. ; Cox, Dermot ; Salvato, Maria S.
• Description:
  Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathogenic members of the families Flaviviridae, Bunyaviridae, Arenaviridae, and Filoviridae. A systematic search was performed through the main medical electronic databases using as parameters all current findings concerning platelets in VHF. Additionally, the review contains information from conference proceedings.
• Subjects:
  Blood Platelets Hemorrhagic Fevers, Viral Host-Pathogen Interactions Humans RNA Viruses
• Source:
  PLoS Negl Trop Dis. 2014; 8(6).
• Document Type:
  Journal Article
• Funding:
  5RC2CA149001/CA/NCI NIH HHS/United States ; AI068961/AI/NIAID NIH HHS/United States
• Volume:
  8
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4527b80076d562a4b90e774669fbd4e9a296556aa3361fa7d32199916115e920
• Download URL:
  https://stacks.cdc.gov/view/cdc/24807/cdc_24807_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]