The Relationship of vitamin B6 status to median nerve function and carpal tunnel syndrome among active industrial workers.

Details

• Personal Author:
  Albers JW ; Franzblau, Alfred ; Johnston EC ; Kelley MP ; Rock CL ; Werner RA
• Description:
  The relationship of vitamin-B6 status to median nerve function and carpal tunnel syndrome was examined in active industrial workers. In order to address potential weaknesses in previously reported studies, this study incorporated a large number of randomly selected subjects, standardized electrophysiologic assessment of nerve function, and multiple complementary measurements of vitamin-B6 status. The study group was composed of 125 randomly selected active workers (67% females) from two industrial facilities. The workers completed a self administered symptoms questionnaire and underwent electrodiagnostic testing of the median and ulnar sensory nerves. Vitamin-B6 status was evaluated using the erythrocyte glutamic-pyruvic-transaminase (EGPT) assay and quantification of plasma pyridoxal-5'-phosphate. Vitamin-B6 status was normal in most subjects; an abnormal EGPT index was found in only ten workers. Median mononeuropathy was detected in 31 participants. Vitamin-B6 status was not related to self reported symptoms associated with carpal tunnel syndrome or electrophysiologically determined median or ulnar nerve function. The authors conclude that the findings do not support a relationship between carpal tunnel syndrome among active industrial workers and vitamin-B6 status; the routine prescription of vitamin-B6 to patients with carpal tunnel syndrome should therefore be reconsidered. [Description provided by NIOSH]
• Subjects:
  Age Factors Cumulative Trauma Disorders Ergonomics Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  NIOSH Publication; NIOSH Grant; Grants other; Occupational medicine; Humans; Carpal tunnel syndrome; Cumulative trauma disorders; Vitamins; Nerve function; Dietary effects; Electrophysiological measurements; Musculoskeletal system disorders; Musculoskeletal system; Repetitive work; Cumulative trauma; Carpal tunnel syndrome; Hand injuries; Vitamins; Age factors; Ergonomics
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  485-491
• Volume:
  38
• Issue:
  5
• NIOSHTIC Number:
  nn:00235782
• Citation:
  J Occup Environ Med 1996 May; 38(5):485-491
• Contact Point Address:
  Environmental & Indust Health the University of Michigan 1420 Washington Heights Ann Arbor, MI 48109-2029
• Federal Fiscal Year:
  1996
• NORA Priority Area:
  Grants Other
• Performing Organization:
  University of Michigan at Ann Arbor, Ann Arbor, Michigan
• Peer Reviewed:
  True
• Start Date:
  19920901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  19960430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247885/cdc_247885_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]