An investigation of multiple biomarkers among workers exposed to styrene and styrene-7,8-oxide.

Details

• Personal Author:
  Bodell W ; Rappaport SM ; Symanski, Elaine ; Yager JW ; Yeowell-O'Connell K
• Description:
  In this longitudinal study, the effects of styrene (100425) and styrene-7,8-oxide (96093) (SO) exposure were examined among 48 reinforced plastics workers. Blood, air, and exhaled air samples were collected from each worker. Among all subjects, the mean styrene exposure level was 64.3mg/m3, while the mean SO exposure level was 159 micrograms per cubic meter (microg/m3). The mean exhaled styrene concentration was 1.76mg/m3. The mean sister chromatid exchange (SCE) rate was 0.41 exchanges per cell. Mean albumin adduct levels ranged from 0.286 nanomoles per gram (nmol/g) of albumin to 1.68nmol/g. Mean DNA adduct levels were significantly higher among smokers than among nonsmokers. The mean SCEs among smokers, 6.73 per cell, were significantly higher than those among nonsmokers, 6.07 per cell. Classification according to job reduced the ranges of exposures and biomarkers. Styrene exposure was highly correlated with the exhaled styrene concentration, with a coefficient of 0.910. Styrene exposure was also correlated with SO exposure, with a coefficient of 0.327. Biomarker levels were significantly correlated with styrene and SO exposure. The correlation coefficients between DNA adduct levels and styrene exposure, albumin adduct levels and SO exposure, and SCEs and SO exposure were higher among nonsmokers than among smokers. When the coefficients were computed for specific jobs, the coefficients for SO exposure and SO biomarkers, 0.709 to 0.966, were higher than those for styrene exposure and SO biomarkers, 0.017 to 0.530. The main effects ratio of styrene to SO was calculated as 4.65x10(-4) micromoles of SO per micromole of styrene, indicating that SO exposure was the main cause of increased SO biomarkers. The authors conclude that decreases in SO exposure may be more crucial than decreases in styrene exposure to the reduction of the health hazards in the reinforced plastics industry. [Description provided by NIOSH]
• Subjects:
  Hematologic Tests Occupational Exposure Occupational Health Plastics Safety
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Grants-other; Humans; Plastics-industry; Occupational-exposure; Biological-monitoring; Blood-analysis; DNA-adducts; Genotoxic-effects
• ISSN:
  0008-5472
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  56
• Issue:
  23
• NIOSHTIC Number:
  nn:00234920
• Citation:
  Cancer Res 1996 Dec; 56(23):5410-5416
• Contact Point Address:
  Biomedical & Environ Hlth Scis University of California School of Public Health Berkeley, CA 94720
• CAS Registry Number:
  Styrene (CAS RN 100-42-5) ; Styrene oxide (CAS RN 96-09-3)
• Federal Fiscal Year:
  1997
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of California Berkeley, Berkeley, California
• Peer Reviewed:
  True
• Start Date:
  19850901
• Source Full Name:
  Cancer Research
• End Date:
  19931227
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247876/cdc_247876_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]