Health care worker exposure to aerosolized ribavirin: biological and air monitoring.

Details

• Personal Author:
  Baron, Sherry L. ; Connor JD ; Decker, John A. ; Deitchman SD ; Shults, Ruth A.
• Description:
  Urinary ribavirin (36791045) concentrations were measured post work shift for occupationally exposed nurses and respiratory therapists, and full shift personal breathing zone air concentrations were measured during the use of different administration units. Post work shift urine samples were collected from 36 exposed health care workers for a total of 48 shifts. Twenty one of the 48 samples contained detectable ribavirin levels. Of the 26 samples provided by nurses, 16 contained ribavirin; of 22 samples provided by respiratory therapists, five contained ribavirin. Urinary ribavirin levels were significantly higher in nurses than in respiratory therapists. Full shift breathing zone air samples were collected from nurses over 16 shifts. Ribavirin administration methods included the Aerosol Delivery Hood (ADH), the ADH or a mist tent enclosed by a Demistifier isolation chamber, a mist tent alone, or direct coupling to a mechanical ventilator. Ribavirin levels were lower when it was administered by ventilator or by an aerosol administration unit enclosed by an aerosol containment tent. Administration units not enclosed by an aerosol containment tent were associated with high breathing zone levels. The authors recommend that aerosol containment devices be used with all types of ribavirin administration units except mechanical ventilators. [Description provided by NIOSH]
• Subjects:
  Biopharmaceutics Health Care Facilities Workforce And Services Health Personnel Occupational Exposure Occupational Health Safety Urine
• Keywords:
  NIOSH-Author; Biological-monitoring; Occupational-exposure; Health-care-personnel; Pharmaceuticals; Medical-equipment; Urinalysis; Humans; Breathing-zone
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  257-263
• Volume:
  38
• Issue:
  3
• NIOSHTIC Number:
  nn:00230169
• Citation:
  J Occup Environ Med 1996 Mar; 38(3):257-263
• Contact Point Address:
  Ruth Shults, MPH, Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, 4770 Buford Highway, Northeast, Mailstop K-63, Atlanta, GA 30341-3724
• CAS Registry Number:
  Ribavirin (CAS RN 36791-04-5)
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247828/cdc_247828_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]