Mammalian metabolism of terpenoids. I. Reduction and hydroxylation of camphor and related compounds.

Details

• Personal Author:
  Leibman KC ; Ortiz E
• Description:
  The metabolism of D-camphor (464493), L-camphor (464482), and some related compounds was investigated in-vivo in the dog and rabbit, and in-vitro in liver preparations from rats and rabbits. A male beagle-dog was given 1 gram (g) of D-camphor four times a day for 7 days. A white New-Zealand-rabbit was given a suspension of 300 milligrams of D-camphor by stomach tube, and urine was collected for 24 hours. Both the dog and the rabbit excreted three hydroxycamphors in the urine: 5-exo-hydroxycamphor, 5-endo- hydroxycamphor, and a 3-hydroxycamphor identical in thin layer and gas chromatographic characteristics with 3-endo-hydroxycamphor. The metabolism of L-camphor proceeded in much the same manner as that of D-camphor. However, in the reductive metabolism of the two camphor isomers there were some significant differences. No reduction of D- camphor was noted in rat liver 9000g supernatant fraction, but a modest extent of reduction of L-camphor occurred in this preparation. The major form was the endoreduction, although the ratio of borneol to isoborneol was much smaller than in the product of reduction of D-camphor by the analogous rabbit liver fraction. In the rabbit liver 9000g supernatant fraction, reduction of the 20- keto group of L-camphor occurred to a much lesser extent than did that of D-camphor. The stereoselectivity of the reaction was also reversed with isoborneol predominating in the reduction products. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Laboratories Occupational Health Safety
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Grants-other; Laboratory-animals; Metabolic-study; In-vitro-studies; In-vivo-studies
• ISSN:
  0090-9556
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  1
• Issue:
  2
• NIOSHTIC Number:
  nn:00190461
• Citation:
  Drug Metab Dispos 1973 Mar; 1(2):543-551
• Contact Point Address:
  Pharmacology and Therapeutics Univ of Florida Coll of Med Dept of Pharma & Therapeutics Gainesville, Fla 32601
• CAS Registry Number:
  (-)-Camphor (CAS RN 464-48-2) ; (+)-Camphor (CAS RN 464-49-3)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Florida Gainesville, Gainesville, Florida
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Drug Metabolism and Disposition
• End Date:
  19841130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247700/cdc_247700_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]