Comparative Antimutagenicity of Chlorophyllin and Five Other Agents against Aflatoxin B1-Induced Reversion in Salmonella typhimurium Strain TA98.

Details

• Personal Author:
  Brockman HE ; Ong T ; Stewart J ; Whong Z
• Description:
  The antimutagenic activity of chlorophyllin against aflatoxin-B1 (1162658) was compared to that of vitamin-A, vitamin-C, vitamin-E, retinoic-acid, and beta-carotene using the plate incorporation reversion test in the presence of S9 activation with the Salmonella- typhimurium strain (TA-98). Aflatoxin-B1 induced reversion was inhibited by chlorophyllin, vitamin-A, retinoic-acid, and beta- carotene with maximal inhibition of 100, 100, 55, and 45 percent, respectively. Chlorophyllin induced inhibition of aflatoxin induced reversion occurred only when the agent was administered at the time of the aflatoxin treatment. The retinoids, vitamin-A and retinoic- acid, produced the greatest inhibition of aflatoxin mutagenicity at a plate concentration of 26 nanomoles; but the rank order of inhibitory activity from highest to lowest at plate concentrations of 860 and 2600 nanomoles was chlorophyllin, vitamin-A, retinoic- acid, and beta-carotene. The agents tested showed no lethal effects against the S-typhimurium strain (TA-98), and no toxic effects were observed against the background lawn growth on the plates used to count the revertant colonies. None of the compounds selected against the revertants of (TA-98). [Description provided by NIOSH]
• Subjects:
  Mutagens Mycoses Occupational Health Safety
• Keywords:
  Author Keywords: Vitamin A; Vitamin C; Vitamin E; Retinoic Acid; B-carotene NIOSH-Author; Mutagens; Mycotoxins; Bacterial-cultures; Microbial-test-systems; Vitamins; Mutagenesis;
• ISSN:
  0270-3211
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  215-224
• Volume:
  8
• Issue:
  4
• NIOSHTIC Number:
  nn:00183278
• Citation:
  Teratog, Carcinog, Mutagen 1988 Jan; 8(4):215-224
• Contact Point Address:
  Wen-Zong Whong, NIOSH, 944 Chestnut Ridge Road, Morgantown, WV 26505
• CAS Registry Number:
  Aflatoxin B1 (CAS RN 1162-65-8)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Teratogenesis, Carcinogenesis, and Mutagenesis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247647/cdc_247647_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]