HLA-B8 in sarcoidosis.

Details

• Personal Author:
  Elliott JA ; Hancock JS ; Heise ER ; Major, Pervis C. ; Marx JJ Jr. ; Mentnech MS ; Mull JC ; Olenchock, Stephen A. ; Pearson DJ ; Price CD ; Spurgeon DE
• Description:
  The association between sarcoidosis and histocompatibility locus antigens (HLA) (sometimes referred to as human leucocyte antigens) was explored. A total of 174 subjects with sarcoidosis were compared with a reference group of 97 individuals who were free of lung disease. HLA typing of blood samples was accomplished using a two stage microcytotoxicity technique. Blood grouping for the ABO blood types and other blood groups used commercial reagents. The literature on the subject suggested that the antigens HLA-B7, HLA- B8, or HLA-A1 might be associated with sarcoidosis, and these antigens were investigated. The HLA-C antigens had not been tested previously, and they were included in the study. When the participants were grouped by blood type, the only correlation between sarcoidosis and blood type that differed between the patient and reference groups was that the sarcoidosis patients had a lower than expected frequency of the Rh(d)+ blood group. HLA-B8 occurred in 15 percent of the reference group and in 29 percent of the patients with sarcoidosis. The authors conclude that only HLA-B8 shows a statistically significant association with sarcoidosis. [Description provided by NIOSH]
• Subjects:
  Case Reports Diagnosis Hazardous Substances Hematologic Tests Occupational Health Safety
• Keywords:
  NIOSH-Author; Clinical-symptoms; Physiological-response; Clinical-diagnosis; Disease-incidence; Case-studies; Blood-analysis; Pathogenesis; Toxic-effects; Serological-techniques
• ISSN:
  0003-4738
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  151-153
• Volume:
  47
• Issue:
  3
• NIOSHTIC Number:
  nn:00131247
• Citation:
  Ann Allergy 1981 Sep; 47(3):151-153
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Allergy
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247527/cdc_247527_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]