Studies of endocrine function in "isolated" gonadotropin deficiency.

Details

• Personal Author:
  Boyar RM ; Finkelstein JW ; Hellman L ; Kapen S ; Weitzman E ; Witkin M
• Description:
  Six chromatin-negative young men with hypogonadotropic hypogonadism were studied in an attempt to clarify and define the endocrine abnormalities responsible for this disorder. Five of the six patients had associated congenital anomalies involving the skeletal system or midline facial structures. Pituitary function studies showed normal thyroid and adrenal function. Evaluation of pituitary- gonadal function showed normal prepubertal concentrations of luteinizing-hormone (9002679), follicle-stimulating-hormone (9002759) and testosterone (58220). These observations show that hypogonadotropic hypogonadism is associated with a high frequency of congenital abnormalities, subnormal sleep-mediated growth-hormone (9002726) release, plasma luteinizing-hormone and follicle- stimulating-hormone concentrations indistinguishable from normal prepubertal boys and normal plasma testosterone responses to long human chorionic-gonadotropin (9002613) treatment. [Description provided by NIOSH]
• Subjects:
  Endocrine System Endocrine System Diseases Growth Musculoskeletal Diseases Occupational Health Safety Urogenital System
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Grants-other; Endocrine-system-disorders; Endocrine-function; Musculoskeletal-system-disorders; Sex-hormones; Growth-disorders; Gonadal-functions; Reproductive-system; Pituitary-functions; Reproduction-hormones
• ISSN:
  0021-972
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  64-72
• Volume:
  36
• Issue:
  1
• NIOSHTIC Number:
  nn:00038662
• Citation:
  J Clin Endocrinol Metab 1973 Jan; 36(1):64-72
• Contact Point Address:
  Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
• CAS Registry Number:
  Chorionic gonadotropin (CAS RN 9002-61-3) ; Follicle-stimulating hormone (CAS RN 9002-75-9) ; Growth hormone (CAS RN 9002-72-6) ; Luteinizing hormone (CAS RN 9002-67-9) ; Testosterone (CAS RN 58-22-0)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Grants Other ; Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Montefiore Hospital and Medical Center, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  19761231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247397/cdc_247397_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]