Maternal occupational pesticide exposure and risk of hypospadias in the National Birth Defects Prevention Study

Details

• Personal Author:
  Lawson, Christina C. ; Olney RS ; Reefhuis J ; Rocheleau CM ; Romitti PA ; Sanderson, Wayne T. ; Stewart PA ; Sun L ; Waters MA
• Description:
  BACKGROUND: Hypospadias is a common congenital malformation among men in which the urethral opening is ventrally displaced. Pesticide exposure has been suggested as a possible etiologic factor, but previous epidemiologic studies have produced inconsistent results. METHODS: We used data from the National Birth Defects Prevention Study (NBDPS), a population-based case-control study, to examine maternal occupational exposure to fungicides, insecticides, and herbicides among 647 hypospadias case infants and 1496 unaffected male control infants with estimated delivery dates from October 1997 to December 2002. Periconceptional (1 month before conception through the first trimester of pregnancy) pesticide exposures were assigned by an expert rater, assisted by a job-exposure matrix (JEM), from a job history completed by mothers during a telephone interview. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with multivariable logistic regression, and adjusted for relevant covariates. RESULTS: Maternal periconceptional occupational exposure to any pesticides (yes/no) was not associated with an increased risk of hypospadias (OR = 0.78; 95% CI = 0.61-1.01). Maternal occupational periconceptional pesticide exposure type (insecticides, fungicides, and herbicides) and estimated quantity also showed no significantly increased risk of hypospadias and no evidence of a dose-response relationship; however, the estimated pesticide exposure levels in this population were low. CONCLUSION: Using broad classes of insecticides, herbicides, and fungicides, we found no evidence that low intensity maternal periconceptional occupational pesticide exposure was a risk factor for hypospadias. Birth Defects Research (Part A) 2011. [Description provided by NIOSH]
• Subjects:
  Endocrine System Endocrine System Diseases Environmental Exposure Environmental Health Environmental Pollution Fungi Fungicide, Industrial Herbicides Insecticides Men Occupational Health Safety Urogenital Diseases Urogenital System

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• Keywords:
  Agrochemicals Author Keywords: Hypospadias Birth-defects Birth Defects Congenital-effects Endocrine-system Endocrine-system-disorders Endocrine Disruption Environmental-exposure Environmental-factors Environmental-hazards Exposure-levels Exposure-limits Fungicides Humans Pesticides Reproductive-system-disorders Urogenital-system Urogenital-system-disorders Urogenital Malformation

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• ISSN:
  1542-0752
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Iowa ; Ohio ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; Virginia ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  91
• Issue:
  11
• NIOSHTIC Number:
  nn:20039752
• Citation:
  Birth Defects Res A Clin Mol Teratol 2011 Nov; 91(11):927-936
• Contact Point Address:
  Carissa M. Rocheleau, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-15, Cincinnati, OH 45226
• Email:
  CRocheleau@cdc.gov
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Battelle
• Peer Reviewed:
  True
• Source Full Name:
  Birth Defects Research Part A: Clinical and Molecular Teratology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3b5f7f8df7002b06566b8bf4f438d18a2eafb6c909e91ecc05ab6b9bd82df6465c7a048526766b9c1b0d902c75fb1d37207276b5fa5994a3da0b9787422fb5c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/192870/cdc_192870_DS1.pdf
• File Type:
  [PDF - 110.86 KB ]