Neurologic effects of solvents in older adults. The "UW Retired Worker Study."

Details

• Personal Author:
  Checkoway, Harvey ; Claypoole K ; Dager S ; Daniell WE ; Rosenstock, Linda ; Smith-Weller T ; Townes B ; White D
• Description:
  The possibility that previous occupational exposure to solvents might be associated with clinically significant neurological dysfunction in older adults was investigated in a cross sectional study. Subjects included 67 painters, 22 aerospace painters and fuel cell sealers, and a comparison group of 126 carpenters. All subjects had retired from regular employment at least 1 year prior to the study. As measured by semiquantitative exposure index, the cumulative histories of lifetime occupational solvent exposure were on the average comparable in the two exposed study groups, painters and aerospace workers. The carpenters differed from the other groups in solvent exposure by several orders of magnitude. The painters had a significantly higher history of consuming alcoholic beverages than did the other two study groups. The painters had a significantly higher score on the Beck Depression Inventory, a measure of current depressive symptoms. The painters reported significantly more general neurologic symptoms than did the other two groups. The aerospace workers showed much greater evidence of possible adverse effects from former solvent exposure on current neuropsychological function than did the painters when determined by reasoning and memory tests, memory visual motor speed and motor tests. No evidence of persistent effects on liver or renal excretory function was seen in solvent exposed subjects. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Aerospace Medicine Nervous System Nervous System Diseases Occupational Exposure Occupational Health Paint Safety Solvents Wood
• Keywords:
  Neurotoxic-effects; Organic-solvents; Solvent-vapors; Nervous-system-disorders; Painting; Aerospace-workers; Woodworking-industry; Occupational-exposure
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-110
• NIOSHTIC Number:
  nn:00218696
• NTIS Accession Number:
  PB94168382
• Citation:
  Occupational Medicine Programs, Department of Medicine, University of Washington, Seattle, Washington 1993 Nov; :1-110
• Contact Point Address:
  Medicine Harbrview Medical Ctr 325 9Th Ave Seattle, WA 98104
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  False
• Start Date:
  19890930
• Source Full Name:
  Occupational Medicine Programs, Department of Medicine, University of Washington, Seattle, Washington
• End Date:
  19920929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246284/cdc_246284_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]