Respiratory effects of inhaled gases and aerosols.

Details

• Personal Author:
  Covert DS ; Frank R ; Holub R ; Horike N ; Koenig JQ ; Morgan MS
• Description:
  Studies of the effects of exposure to combinations of sulfur-dioxide (7446095) with sodium-sulfate (7757826) or ammonium-sulfate (7783202) at controlled relative humidities on the respiratory systems of animals or man were reported. Female COBS-guinea-pigs were exposed to 5 parts per million (ppm) SO2, 1mg/m3 ammonium- sulfate, or ammonium-sulfate plus 1, 5 or 10ppm SO2. When SO2 was given alone, the effects implicated the upper and/or central airways and occurred early in the exposure period. Effects associated with ammonium-sulfate exposure implicated the peripheral airways and either appeared or extended into the latter half of the exposure period. For human studies, 18 nonsmoking adults were exposed to a droplet aerosol of ammonium-sulfate (1.0mg/m3) alone; a dry aerosol of ammonium-sulfate plus SO2, or a droplet aerosol of ammonium- sulfate plus SO2. In these healthy subjects the average short term effects of the two inhaled agents, alone or combined, were slight. Ammonium-sulfate was mildly irritating alone, but did not show evidence of biological interaction with SO2. No evidence for additive or synergistic action was noted. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Aerosols Irritants Laboratories Occupational Health Respiratory Tract Diseases Safety Sulfur Compounds
• Keywords:
  NIOSH-Grant; Pulmonary-system-disorders; Respiratory-irritants; Aerosols; Laboratory-animals; Humans; Sulfur-compounds
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-55
• NIOSHTIC Number:
  nn:00188713
• NTIS Accession Number:
  PB89227862
• Citation:
  Department of Environmental Health, University of Washington, Seattle, Washington 1977 Jul; :1-55
• Contact Point Address:
  Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
• CAS Registry Number:
  Ammonium sulfate (CAS RN 7783-20-2) ; Sodium sulfate (CAS RN 7757-82-6) ; Sulfur dioxide (CAS RN 7446-09-5)
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Washington, Seattle
• Peer Reviewed:
  False
• Start Date:
  19701001
• Source Full Name:
  Department of Environmental Health, University of Washington, Seattle, Washington
• End Date:
  19770331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246192/cdc_246192_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]