Occupational health hazards in skin injury by mitomycin C.

Details

• Personal Author:
  Kowal CD ; Kowal CD
• Description:
  The incidence of cutaneous intradermal injuries resulting from exposure to mitomycin-C (50077) (MMC) was studied. Dehaired mice received topical MMC intradermal injections followed by various topical antidotal treatments. Skin toxicity studies demonstrated a dose dependent toxicity with MMC exposures. Within 1 to 5 days following injection, ulcers appeared with induration and erythema 20 and 10 fold greater in size than was the central ulcer, respectively. By day five, erythema tended to peak and then resolve over a 2 to 4 week period. Induration also peaked at day five but remained visible up to 7 weeks. Ulcers due to MMC exposure had a central necrotic appearance and resembled adriamycin induced ulcers. While larger doses did not produce correspondingly larger ulcers, they did require longer periods of time to heal. For most of the pharmacologic agents tested, no antidotal activity was noted. Marked antidotal activity was observed following topical administration of dimethylsulfoxide, with complete protection against MMC ulceration being provided following a low dose application. For high dose MMC, a single topical application of DMSO immediately after MMC was most effective. Some therapeutic benefit was derived from treatment with sodium-thiosulfate, but this was much less than that obtained with DMSO therapy. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Antineoplastic Agents Dermatitis Laboratories Occupational Health Safety Skin
• Keywords:
  NIOSH-Grant; Dermatitis; Antineoplastic-agents; Medical-treatment; Skin-exposure; Skin-irritants; Laboratory-animals
• Series:
  Grant Final Reports   ; Grant Final Reports  
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report ; Final Grant Report
• Place as Subject:
  Maine ; OSHA Region 1 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs ; OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-30
• NIOSHTIC Number:
  nn:00187453
• NTIS Accession Number:
  PB89201016
• Citation:
  Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania 1988 Nov; :1-30
• Contact Point Address:
  Medicine University of Pittsburgh 922 Scaife Hall Pittsburgh, PA 15261
• CAS Registry Number:
  Mitomycin C (CAS RN 50-07-7) ; Mitomycin C (CAS RN 50-07-7)
• Federal Fiscal Year:
  1989
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  False
• Start Date:
  19840701
• Source Full Name:
  Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania
• End Date:
  19870331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246183/cdc_246183_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]