Coal liquids: skin toxicity and mutagenicity studies.

Details

• Personal Author:
  Bickers DR
• Description:
  Summaries were included in this final progress report of the various research publications generated during the study of the effects of coal-tar (8007452) on xenobiotic metabolism in the skin. Specifically information was sought concerning the activity of aryl- hydrocarbon-hydroxylase (AHH). Neonatal rats were used to study the enzyme activity in epidermal, dermal, and other bodily tissues. Significant induction of AHH was noted in the tissues following topical application of benzo(a)pyrene (50328) (BP) or the Aroclor- 1254 (11097691) mixture. Skin enzymes demonstrated a greater activity than other extrahepatic tissues. Primary results of research into the induction of skin and liver AHH activities following topical application of coal tar were reported along with the results of coal tar application and subsequent induction of hepatic cytosolic glutathione-S-transferase and microsomal epoxide- hydrolase and aminopyrine N-demethylase activities. The drug metabolizing enzyme activity and the hemeprotein cytochrome-P-450 and epoxide-hydrolase activities were compared in skin, epidermal, and dermal tissues following coal tar administration and the enzyme activities in the liver, lung, kidney, and intestine were also examined. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Coal Coal Mining Coal Tar Dermatitis Hydrocarbons Laboratories Mining Occupational Health Polycyclic Aromatic Hydrocarbons Safety Skin

  More +
• Keywords:
  NIOSH-Grant; Dermatitis; Liver-microsomal-enzymes; Chlorinated-hydrocarbons; Aromatic-hydrocarbons; Coal-tar-pitch; Coal-workers; Coal-products; Skin-exposure; Laboratory-animals
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:00182720
• NTIS Accession Number:
  PB89130769
• Citation:
  Department of Dermatology, Case Western Reserve University, Cleveland, Ohio. 1985 Jan; :1-9
• Contact Point Address:
  Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
• CAS Registry Number:
  Benzo[a]pyrene (CAS RN 50-32-8) ; Coal tar (CAS RN 8007-45-2) ; PCB-1254 (CAS RN 11097-69-1)
• Federal Fiscal Year:
  1985
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  Case Western Reserve University, Cleveland, Ohio
• Peer Reviewed:
  False
• Start Date:
  19800929
• Source Full Name:
  Department of Dermatology, Case Western Reserve University, Cleveland, Ohio
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246151/cdc_246151_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]