Hair as a monitor of toxic chemicals exposure.

Details

• Personal Author:
  Adams S ; Baumgartner WA ; Jones PF
• Description:
  The possibility of using hair analysis as a monitor of exposure to hydrazines and polychlorinated-biphenyls (1336363) (PCBs) was investigated. Two female Hartley-guinea-pigs injected with 0.6 milligrams (mg) of Aroclor-1254 (11097691) had analyzable concentrations of the PCB in their hair. Analysis was made using glass capillary gas chromatography with an electron capture detector. The levels ranged from 10 picograms/milligram (pg/mg) of Aroclor-1254 in washed hair to 100pg/mg in unwashed hair. Female Fischer-344-rats injected intraperitoneally with 60mg/kg unsymmetrical dimethyl-hydrazine (57147) (UDMH), 10mg/kg monomethyl- hydrazine (60344) (MMH) and/or 10mg/kg hydrazine (302012) did not have detectable amounts of these chemicals in their hair at 14, 30 or 42 days after injection. The hair samples did take up the hydrazines when suspended above solutions of the test compounds. The authors concluded that analyzing the PCB content of hair may be useful in providing a history of on the job PCB exposure. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Chromatography Environmental Exposure Environmental Pollution Insecticides Laboratories Occupational Health Safety
• Keywords:
  NIOSH-Grant; Biological-monitoring; Environmental-contamination; Environmental-pollution; Insecticides; Pesticides; Chromatographic-analysis; Laboratory-animals
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:00181248
• NTIS Accession Number:
  PB88252689
• Citation:
  Aerospace Corporation, Los Angeles, California, Aerospace Report No. ATR-0082(7950)-1, 1982 Aug; :1-9
• Contact Point Address:
  Analytical Sciences Aerospace Corporation 2350 E EL Segundo EL Segundo, Calif 90245
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; 1,1-Dimethylhydrazine (CAS RN 57-14-7) ; Hydrazine (CAS RN 302-01-2) ; Methylhydrazine (CAS RN 60-34-4) ; PCB-1254 (CAS RN 11097-69-1)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Aerospace Corporation, El Segundo, California
• Peer Reviewed:
  False
• Start Date:
  19800929
• Source Full Name:
  Aerospace Corporation, Los Angeles, California, Aerospace Report No. ATR-0082(7950)-1
• End Date:
  19820831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246115/cdc_246115_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]