Intraneural connective tissue proliferation of the median nerve in the carpal tunnel.

Details

• Personal Author:
  Armstrong TJ ; Castelli WA ; Diaz-Perez R ; Evans FG
• Description:
  In order to evaluate the proliferation of the intraneural connective tissue and its intrinsic vasculature, segments were taken from the median nerve from the distal fourth of the right forearm and the carpal tunnel area in 23 embalmed human cadavers. The percentage of the cross sectional area formed by fascicles plus perineuria in the round cross sections of the nerve (proximal to the flexor retinaculum) was significantly greater in both males and females than in the flat cross sections of the nerve within the carpal tunnel. The flattened cross sections of the median nerve obtained from the carpal tunnel exhibited circumscribed laminated masses of fibrous connective tissue. These were identified as Renaut bodies and their presence may indicate abnormal intraneural proliferation of connective tissue as well. The thicker epineurial and perineurial layers of the median nerve within the carpal tunnel probably represents localized areas of subclinical reactive connective tissue hyperplasia. There were no comparable changes in the nerve fascicles of the median nerve proximal to the carpal tunnel. Remarkable proliferation of the intraneural connective tissue was noted in the flattened sections of most nerves. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Cumulative Trauma Disorders Musculoskeletal Diseases Musculoskeletal System Nervous System Diseases Occupational Health Safety
• Keywords:
  NIOSH-Grant; Arm-injuries; Hand-injuries; Musculoskeletal-system-disorders; Carpal-tunnel-syndrome; Nervous-system-disorders; Cumulative-trauma-disorders
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-16
• NIOSHTIC Number:
  nn:00181039
• NTIS Accession Number:
  PB88246970
• Citation:
  Department of Anatomy, University of Michigan, Ann Arbor, Michigan, 1984 Jan; :1-16
• Contact Point Address:
  Industrial & Operations Engr University of Michigan 2260 G G Brown Laboratory Ann Arbor, Mich 48109
• Federal Fiscal Year:
  1984
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  University of Michigan at Ann Arbor, Ann Arbor, Michigan
• Peer Reviewed:
  False
• Start Date:
  19760929
• Source Full Name:
  Department of Anatomy, University of Michigan, Ann Arbor, Michigan
• End Date:
  19830731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246111/cdc_246111_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]