Antibody-mediated lung defenses and humoral immunodeficiency.

Details

• Personal Author:
  Landreth KS ; Weissman, David N. ; Wilson NW
• Description:
  Immunoglobulins (Ig) are proteins with the ability to recognize and bind a broad diversity of antigens as well as to modulate subsequent effector responses to bound antigens. As a result, Ig plays a key role in both normal respiratory tract homeostasis and in pathology of the lung. Appropriate Ig responses promote clearance of antigens from the lung and minimize injury responses. In contrast, inadequate or inappropriate Ig responses can allow or actually induce lung injury. In this chapter, we briefly review mechanisms underlying antibody synthesis and secretion by B cells, physical and functional characteristics of Ig, and features specific to pulmonary antibody immunity. Humoral immunodeficiency syndromes relevant to the lung are also discussed. [Description provided by NIOSH]
• Subjects:
  Antibodies Antigens Immune System Lung Occupational Health Respiratory System Safety
• Keywords:
  Lung; Immunoglobulins; Antibody-response; Antigens; Immune-system
• ISBN:
  9780070211797
• Publisher:
  McGraw-Hill
• Document Type:
  Text
• Genre:
  Book
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  303-314
• Volume:
  1
• NIOSHTIC Number:
  nn:20000876
• Citation:
  Fishman's pulmonary diseases and disorders, third edition. Fishman AP, Elias JA. Fishman JA, Grippi MA, Kaiser LR, Senior R, eds., New York: McGraw-Hill, 1997 Sep; :303-314
• Editor(s):
  Fishman AP; Elias JA; Fishman JA; Grippi MA; Kaiser LR; Senior R
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  False
• Source Full Name:
  Fishman's pulmonary diseases and disorders, third edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/245778/cdc_245778_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]