Molecular signatures of antibody responses derived from a systems biological study of 5 human vaccines

Li, Shuzhao; Rouphael, Nadine; Duraisingham, Sai; Romero-Steiner, Sandra; Presnell, Scott; Davis, Carl; Schmidt, Daniel S; Johnson, Scott E; Milton, Andrea; Rajam, Gowrisankar; Kasturi, Sudhir; Carlone, George M; Quinn, Charlie; Chaussabel, Damien; Palucka, A Karolina; Mulligan, Mark J; Ahmed, Rafi; Stephens, David S; Nakaya, Helder I; Pulendran, Bali

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Molecular signatures of antibody responses derived from a systems biological study of 5 human vaccines

December 15 2013
By Li, Shuzhao ; Rouphael, Nadine ; Duraisingham, Sai ; ...
Source: Nat Immunol. 15(2):195-204

[PDF-1.80 MB]

English

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Details:

Alternative Title:

Nat Immunol
Personal Author:

Li, Shuzhao ; Rouphael, Nadine ; Duraisingham, Sai ; Romero-Steiner, Sandra ; Presnell, Scott ; ... More +

Li, Shuzhao ; Rouphael, Nadine ; Duraisingham, Sai ; Romero-Steiner, Sandra ; Presnell, Scott ; Davis, Carl ; Schmidt, Daniel S ; Johnson, Scott E ; Milton, Andrea ; Rajam, Gowrisankar ; Kasturi, Sudhir ; Carlone, George M ; Quinn, Charlie ; Chaussabel, Damien ; Palucka, A Karolina ; Mulligan, Mark J ; Ahmed, Rafi ; Stephens, David S ; Nakaya, Helder I ; Pulendran, Bali Less -
Description:

Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling.
Subjects:

[+]

Adolescent Adult Antibody Formation Article Computer Simulation Female Humans Immunity, Active Immunoglobulins Influenza Vaccines Male Meningococcal Infections Meningococcal Vaccines Middle Aged Neisseria Meningitidis Systems Biology Transcriptome Vaccines, Conjugate Yellow Fever Vaccine Young Adult
Source:

Nat Immunol. 15(2):195-204
Pubmed ID:

24336226
Pubmed Central ID:

PMC3946932
Document Type:

Journal Article
Funding:

R37 AI048638/AI/NIAID NIH HHS/United States ; U19 AI090023/AI/NIAID NIH HHS/United States ; R37DK057665/DK/NIDDK NIH HHS/United States ; U19AI090023/AI/NIAID NIH HHS/United States ; P51 OD011132/OD/NIH HHS/United States ; ... More +

R37 AI048638/AI/NIAID NIH HHS/United States ; U19 AI090023/AI/NIAID NIH HHS/United States ; R37DK057665/DK/NIDDK NIH HHS/United States ; U19AI090023/AI/NIAID NIH HHS/United States ; P51 OD011132/OD/NIH HHS/United States ; U19 AI057266/AI/NIAID NIH HHS/United States ; R01 DK057665/DK/NIDDK NIH HHS/United States ; U19AI057266/AI/NIAID NIH HHS/United States ; P51 RR000165/RR/NCRR NIH HHS/United States ; U54AI057157/AI/NIAID NIH HHS/United States ; R37 DK057665/DK/NIDDK NIH HHS/United States ; AI100663-02/AI/NIAID NIH HHS/United States ; UL1 TR000454/TR/NCATS NIH HHS/United States ; U19 AI096187/AI/NIAID NIH HHS/United States ; R37AI48638/AI/NIAID NIH HHS/United States ; UL1 RR025008/RR/NCRR NIH HHS/United States ; U54 AI057157/AI/NIAID NIH HHS/United States Less -
Volume:

15
Issue:

2
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:ac5f5031dcac6b6348858257dd261cb2220eb51b4230316702649f9799f9bf3a
Download URL:

https://stacks.cdc.gov/view/cdc/24538/cdc_24538_DS1.pdf
File Type:

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